"A new computational model of right ventricular hypertrophy"

“右心室肥厚的新计算模型”

• 批准号: 8596459
• 负责人: Michael R Hill
• 金额: $ 4.92万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8596459
• 关键词: Biomechanics; Cardiac Myocytes; Cardiopulmonary; Cell Enlargement; Cell division; Chronic; Collagen; Collagen Fiber; Computer Simulation; Development; Diagnosis; Disease Progression; Effectiveness; Elements; Extracellular Matrix; Failure; Feedback; Functional disorder; Goals; Growth; Health; Hyperplasia; Hypertension; Hypertrophy; Individual; Intervention; Knowledge; Laws; Legal patent; Link; Lung; Lung diseases; Measurement; Measures; Mechanics; Methods; Modeling; Monitor; Myocardial; Myocardial tissue; Myocardium; Organ; Outcome; Patients; Physiology; Play; Process; Property; Pulmonary artery structure; Rattus; Recovery; Right Ventricular Function; Right Ventricular Hypertrophy; Right ventricular structure; Role; Sarcomeres; Scientist; Stress; Structure; Surface; Techniques; Thick; Time; Tissues; Ventricular; Work; blood pump; density; improved; in vivo; model development; mortality; pressure; response; sildenafil; ventricular hypertrophy

DESCRIPTION (provided by applicant): The right ventricle (RV) is primarily involved with pulmonary disorders, such as pulmonary artery hypertension (PAH). PAH imposes increased pressure on the RV, causing a pathological growth and remodeling response (hypertrophy), which leads to RV wall thickening, and eventually to RV failure. New techniques are needed to allow clinicians to obtain in vivo measurements of RV function and to input these parameters into a model that can help predict the progression of this disease. Our ultimate goal is to develop a computational growth and remodeling (G&R) model of the RV response to a pressure overload. This model is to be used clinically to predict the progression of RV hypertrophy and to provide a method to evaluate the effectiveness of new treatment methods. A critical first step toward this goal was the creation of an experimental rat model to study PAH by our group and collaborators; now there is a pressing need for an accurate constitutive stress-strain model, a requirement for computational model development. This project is a major next step in this direction. In this work, we will apply an existing theoretical framework in the form of a constitutive stress-strain model of the healthy RV; we will extend the model to capture the growth and remodeling response to PAH and use a rat model to obtain model parameters; and we will validate this model by assessing its predictive capabilities when compared to results from an intervention. These objectives will be achieved in three specific aims: 1. To develop a constitutive (stress-strain) model for the normal, healthy right ventricle myocardium 2. To extend the model to include the time-evolving growth and remodeling adaptation of the myocardium to changes in wall stress 3. To evaluate the predictive capabilities of the model by comparing the results from the normal myocardium to a rat model of treatment (intervention) of pulmonary artery hypertension

描述（由申请人提供）：右心室（RV）主要涉及肺部疾病，如肺动脉高压（PAH）。PAH对RV施加增加的压力，引起病理性生长和重塑反应（肥大），导致RV壁增厚，最终导致RV衰竭。需要新的技术来允许临床医生获得RV功能的体内测量，并将这些参数输入到可以帮助预测这种疾病的进展的模型中。我们的最终目标是开发一个计算生长和重塑（G&R）模型的RV压力过载的反应。该模型将用于临床预测RV肥大的进展，并提供一种评估新治疗方法有效性的方法。实现这一目标的关键第一步是我们的团队和合作者创建了一个实验大鼠模型来研究PAH;现在迫切需要一个准确的本构应力-应变模型，这是计算模型开发的要求。该项目是朝着这个方向迈出的重要一步。在这项工作中，我们将应用现有的理论框架的健康RV的本构应力-应变模型的形式;我们将扩展该模型，以捕获PAH的生长和重塑反应，并使用大鼠模型获得模型参数;我们将通过评估其预测能力，当从干预的结果相比，验证该模型。这些目标将在三个具体目标实现：1。建立正常健康右心室心肌的本构（应力-应变）模型。为了扩展模型，以包括心肌随时间变化的生长和重构适应壁应力的变化3。通过比较正常心肌与肺动脉高压治疗（干预）大鼠模型的结果，评价模型的预测能力