"A new computational model of right ventricular hypertrophy"

“右心室肥厚的新计算模型”

• 批准号: 8739154
• 负责人: Michael R Hill
• 金额: $ 2.65万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2015-02-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8739154
• 关键词: Biomechanics; Cardiac Myocytes; Cardiopulmonary; Cell Enlargement; Cell division; Chronic; Collagen; Collagen Fiber; Computer Simulation; Development; Diagnosis; Disease Progression; Effectiveness; Elements; Extracellular Matrix; Failure; Feedback; Functional disorder; Geometry; Goals; Growth; Health; Hyperplasia; Hypertension; Hypertrophy; Individual; Intervention; Knowledge; Laws; Legal patent; Link; Lung; Lung diseases; Measurement; Measures; Mechanics; Methods; Modeling; Monitor; Myocardial; Myocardial tissue; Myocardium; Organ; Outcome; Patients; Physiology; Play; Process; Property; Pulmonary artery structure; Rattus; Recovery; Right Ventricular Function; Right Ventricular Hypertrophy; Right ventricular structure; Role; Sarcomeres; Scientist; Stress; Structure; Surface; Techniques; Thick; Time; Tissues; Ventricular; Work; blood pump; density; improved; in vivo; model development; mortality; pressure; response; sildenafil; ventricular hypertrophy

DESCRIPTION (provided by applicant): The right ventricle (RV) is primarily involved with pulmonary disorders, such as pulmonary artery hypertension (PAH). PAH imposes increased pressure on the RV, causing a pathological growth and remodeling response (hypertrophy), which leads to RV wall thickening, and eventually to RV failure. New techniques are needed to allow clinicians to obtain in vivo measurements of RV function and to input these parameters into a model that can help predict the progression of this disease. Our ultimate goal is to develop a computational growth and remodeling (G&R) model of the RV response to a pressure overload. This model is to be used clinically to predict the progression of RV hypertrophy and to provide a method to evaluate the effectiveness of new treatment methods. A critical first step toward this goal was the creation of an experimental rat model to study PAH by our group and collaborators; now there is a pressing need for an accurate constitutive stress-strain model, a requirement for computational model development. This project is a major next step in this direction. In this work, we will apply an existing theoretical framework in the form of a constitutive stress-strain model of the healthy RV; we will extend the model to capture the growth and remodeling response to PAH and use a rat model to obtain model parameters; and we will validate this model by assessing its predictive capabilities when compared to results from an intervention. These objectives will be achieved in three specific aims: 1. To develop a constitutive (stress-strain) model for the normal, healthy right ventricle myocardium 2. To extend the model to include the time-evolving growth and remodeling adaptation of the myocardium to changes in wall stress 3. To evaluate the predictive capabilities of the model by comparing the results from the normal myocardium to a rat model of treatment (intervention) of pulmonary artery hypertension

描述(由申请人提供)：右室(RV)主要涉及肺部疾病，如肺动脉高压(PAH)。PAH对RV施加压力增加，引起病理性生长和重塑反应(肥大)，导致RV壁增厚，最终导致RV衰竭。临床医生需要新的技术来获得RV功能的活体测量，并将这些参数输入到有助于预测这种疾病进展的模型中。我们的最终目标是开发一个RV对压力过载的响应的计算增长和重塑(G&R)模型。该模型将用于临床预测右室肥大的进展，并为评估新的治疗方法的有效性提供一种方法。朝着这个目标迈出的关键的第一步是由我们的团队和合作者创建了一个实验大鼠模型来研究PAH；现在迫切需要一个准确的本构应力-应变模型，这是计算模型开发的要求。这个项目是朝着这个方向迈出的重要的下一步。在这项工作中，我们将以健康房车的本构应力-应变模型的形式应用现有的理论框架；我们将扩展该模型以捕捉PAH的生长和重塑响应，并使用大鼠模型获得模型参数；我们将通过评估该模型与干预结果的预测能力来验证该模型。这些目标将通过三个具体目标来实现：1.建立正常、健康的右室心肌的本构(应力-应变)模型2.扩展该模型以包括心肌随时间演化的生长和重塑对壁应力变化的适应3.通过比较正常心肌和治疗(干预)肺动脉高压的大鼠模型的结果来评价模型的预测能力