Biological & Psychological Factors as Predictors & Indicators of MBSR Response

描述(由申请人提供)：这个RO1项目的总体目标是开发和验证一套生物和心理特征(即生物心理标记物)的“平台”，以预测和指示患者(PT)对基于正念的压力减轻(MBSR)的反应，并验证量身定制的MBSR方法是否提高了MBSR对疾病结果的质量和一致性。我们的初步数据显示，只有溃疡性结肠炎(UC)PTS的一部分对MBSR有反应，并改善了疾病结果，这与文献报道的正念疗法类似的混合结果是一致的，这表明某些生物标记物可能会影响成功。因此，我们假设对MBSR的不同反应是MBSR治疗开始时生物标记物个体差异的结果。目前建议的目标是确定和验证作为MBSR成功的决定因素的预测性生物标记物和可靠的可测量结果。为了实现这一目标，我们提出了两个具体目标。目的：开发一套生物心理标记物，包括关键的心理和生物学特征，这些特征(A)预测UC铂对MBSR的反应；(B)建立一套客观的标记物，证明MBSR对幸福感和UC疾病状态的影响。目的2：验证铂和干预措施定制的影响，以确定(A)基于生物标记物的铂选择是否定制，以及(B)MBSR治疗方案的定制是否会影响MBSR对UC Pts炎症途径和疾病标记物和心理健康的影响。实现这些目标将建立一套客观的铂特征来预测MBSR的有效性，从而提高MBSR作为一种治疗方法的质量和一致性。这将开启MBSR治疗慢性炎症性疾病的新的创新治疗应用。

DESCRIPTION (provided by applicant): The overall goal of this RO1 project is to develop and validate a set "platform" of biological and psychological characteristics (i.e., biopsychomarkers) that predict and indicate patient (Pt) response to mindfulness-based stress reduction (MBSR) and verify that a tailored MBSR approach improves the quality and consistency of MBSR on disease outcomes. Our preliminary data demonstrate that only a subset of ulcerative colitis (UC) Pts respond to MBSR with improved disease outcomes which is in agreement with the literature which reports similar mixed outcomes with mindfulness therapy when it has been applied to other diseases, suggesting that certain biopsychomarkers may impact success. Thus, we hypothesize that the differential responses to MBSR are a consequence of individual variance in biopsychomarkers at the onset of MBSR therapy. The objective of the current proposal is then to identify and verify predictive biopsychomarkers and reliable measurable outcomes as determinants of MBSR success. To achieve this objective we propose two Specific Aims. Aim1: Develop a set of biopsychomarkers, comprised of key psychological and biological characteristics that (a) predict UC Pt response to MBSR and (b) establish an objective set of markers that demonstrate the impact of MBSR on well-being and UC disease state. Aim 2: Verify the impact of Pt and intervention tailoring in order to determine whether (a) tailoring Pt selection based on biopsychomarkers, and whether (b) tailoring of MBSR treatment protocol will impact MBSR's effects on inflammatory pathways and markers of disease and psychological well-being in UC Pts. Accomplishing these Aims will establish an objective set of Pt characteristics that predict effectiveness of MBSR resulting in increased quality and consistency of MBSR as a therapeutic approach. This should open new innovative therapeutic applications for MBSR for the treatment of chronic inflammatory diseases.