Biological & Psychological Factors as Predictors & Indicators of MBSR Response

生物

基本信息

  • 批准号:
    8496498
  • 负责人:
  • 金额:
    $ 43.75万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-09-01 至 2016-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this RO1 project is to develop and validate a set "platform" of biological and psychological characteristics (i.e., biopsychomarkers) that predict and indicate patient (Pt) response to mindfulness-based stress reduction (MBSR) and verify that a tailored MBSR approach improves the quality and consistency of MBSR on disease outcomes. Our preliminary data demonstrate that only a subset of ulcerative colitis (UC) Pts respond to MBSR with improved disease outcomes which is in agreement with the literature which reports similar mixed outcomes with mindfulness therapy when it has been applied to other diseases, suggesting that certain biopsychomarkers may impact success. Thus, we hypothesize that the differential responses to MBSR are a consequence of individual variance in biopsychomarkers at the onset of MBSR therapy. The objective of the current proposal is then to identify and verify predictive biopsychomarkers and reliable measurable outcomes as determinants of MBSR success. To achieve this objective we propose two Specific Aims. Aim1: Develop a set of biopsychomarkers, comprised of key psychological and biological characteristics that (a) predict UC Pt response to MBSR and (b) establish an objective set of markers that demonstrate the impact of MBSR on well-being and UC disease state. Aim 2: Verify the impact of Pt and intervention tailoring in order to determine whether (a) tailoring Pt selection based on biopsychomarkers, and whether (b) tailoring of MBSR treatment protocol will impact MBSR's effects on inflammatory pathways and markers of disease and psychological well-being in UC Pts. Accomplishing these Aims will establish an objective set of Pt characteristics that predict effectiveness of MBSR resulting in increased quality and consistency of MBSR as a therapeutic approach. This should open new innovative therapeutic applications for MBSR for the treatment of chronic inflammatory diseases.
描述(由申请人提供):该 RO1 项目的总体目标是开发和验证一套生物和心理特征(即生物心理标记)“平台”,用于预测和指示患者 (Pt) 对正念减压 (MBSR) 的反应,并验证定制的 MBSR 方法是否可以提高 MBSR 对疾病结果的质量和一致性。我们的初步数据表明,只有一部分溃疡性结肠炎 (UC) 患者对 MBSR 做出反应,并改善了疾病结果,这与文献一致,该文献报道了正念疗法应用于其他疾病时的类似混合结果,表明某些生物心理标志物可能会影响成功。因此,我们假设对 MBSR 的不同反应是 MBSR 治疗开始时生物心理标志物个体差异的结果。当前提案的目标是识别和验证预测性生物心理标志物和可靠的可测量结果,作为 MBSR 成功的决定因素。为了实现这一目标,我们提出了两个具体目标。目标 1:开发一套生物心理标志物,由关键的心理和生物学特征组成,(a) 预测 UC Pt 对 MBSR 的反应,(b) 建立一套客观的标志物,证明 MBSR 对健康和 UC 疾病状态的影响。目标 2:验证 Pt 和干预定制的影响,以确定是否 (a) 根据生物心理标志物定制 Pt 选择,以及 (b) MBSR 治疗方案的定制是否会影响 MBSR 对 UC 患者炎症途径和疾病标志物以及心理健康的影响。实现这些目标将建立一套客观的 Pt 特征,预测 MBSR 的有效性,从而提高 MBSR 作为治疗方法的质量和一致性。这将为 MBSR 治疗慢性炎症性疾病开辟新的创新治疗应用。

项目成果

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STEVAN HOBFOLL其他文献

STEVAN HOBFOLL的其他文献

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{{ truncateString('STEVAN HOBFOLL', 18)}}的其他基金

Research Training/Educaiton Core
研究培训/教育核心
  • 批准号:
    8356077
  • 财政年份:
    2012
  • 资助金额:
    $ 43.75万
  • 项目类别:
Biological & Psychological Factors as Predictors & Indicators of MBSR Response
生物
  • 批准号:
    8672599
  • 财政年份:
    2011
  • 资助金额:
    $ 43.75万
  • 项目类别:
Biological & Psychological Factors as Predictors & Indicators of MBSR Response
生物
  • 批准号:
    8321478
  • 财政年份:
    2011
  • 资助金额:
    $ 43.75万
  • 项目类别:
Biological & Psychological Factors as Predictors & Indicators of MBSR Response
生物
  • 批准号:
    8848039
  • 财政年份:
    2011
  • 资助金额:
    $ 43.75万
  • 项目类别:
Biological & Psychological Factors as Predictors & Indicators of MBSR Response
生物
  • 批准号:
    8261561
  • 财政年份:
    2011
  • 资助金额:
    $ 43.75万
  • 项目类别:
STRESS MEASURES/PSYCHOMETRICS
压力测量/心理测量
  • 批准号:
    7881326
  • 财政年份:
    2010
  • 资助金额:
    $ 43.75万
  • 项目类别:
Terrorism and Traumatic Responding: Exposure and Resiliency Factors
恐怖主义和创伤反应:暴露和复原力因素
  • 批准号:
    7689862
  • 财政年份:
    2006
  • 资助金额:
    $ 43.75万
  • 项目类别:
Terrorism and Traumatic Responding: Exposure and Resiliency Factors
恐怖主义和创伤反应:暴露和复原力因素
  • 批准号:
    7263144
  • 财政年份:
    2006
  • 资助金额:
    $ 43.75万
  • 项目类别:
Terrorism and Traumatic Responding: Exposure and Resiliency Factors
恐怖主义和创伤反应:暴露和复原力因素
  • 批准号:
    7497127
  • 财政年份:
    2006
  • 资助金额:
    $ 43.75万
  • 项目类别:
Terrorism and Traumatic Responding: Exposure and Resiliency Factors
恐怖主义和创伤反应:暴露和复原力因素
  • 批准号:
    7139454
  • 财政年份:
    2006
  • 资助金额:
    $ 43.75万
  • 项目类别:

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