Biological & Psychological Factors as Predictors & Indicators of MBSR Response

生物

基本信息

  • 批准号:
    8261561
  • 负责人:
  • 金额:
    $ 41.19万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-09-01 至 2016-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this RO1 project is to develop and validate a set "platform" of biological and psychological characteristics (i.e., biopsychomarkers) that predict and indicate patient (Pt) response to mindfulness-based stress reduction (MBSR) and verify that a tailored MBSR approach improves the quality and consistency of MBSR on disease outcomes. Our preliminary data demonstrate that only a subset of ulcerative colitis (UC) Pts respond to MBSR with improved disease outcomes which is in agreement with the literature which reports similar mixed outcomes with mindfulness therapy when it has been applied to other diseases, suggesting that certain biopsychomarkers may impact success. Thus, we hypothesize that the differential responses to MBSR are a consequence of individual variance in biopsychomarkers at the onset of MBSR therapy. The objective of the current proposal is then to identify and verify predictive biopsychomarkers and reliable measurable outcomes as determinants of MBSR success. To achieve this objective we propose two Specific Aims. Aim1: Develop a set of biopsychomarkers, comprised of key psychological and biological characteristics that (a) predict UC Pt response to MBSR and (b) establish an objective set of markers that demonstrate the impact of MBSR on well-being and UC disease state. Aim 2: Verify the impact of Pt and intervention tailoring in order to determine whether (a) tailoring Pt selection based on biopsychomarkers, and whether (b) tailoring of MBSR treatment protocol will impact MBSR's effects on inflammatory pathways and markers of disease and psychological well-being in UC Pts. Accomplishing these Aims will establish an objective set of Pt characteristics that predict effectiveness of MBSR resulting in increased quality and consistency of MBSR as a therapeutic approach. This should open new innovative therapeutic applications for MBSR for the treatment of chronic inflammatory diseases. PUBLIC HEALTH RELEVANCE: The overall objective of this proposal is to modify mindfulness therapy to establish reliable and consistent results for patients with chronic inflammatory diseases using ulcerative colitis (UC) as a model inflammatory disease and mindfulness-based stress reduction (MBSR) as the intervention. We will develop and validate a set "platform" of biological and psychological characteristics (i.e., biopsychomarkers) that predict and indicate patient response to MBSR and a tailored MBSR approach that improves well-being and disease outcomes. Identifying this objective set of criteria would increase the quality and consistency of MBSR and lead to a better understanding of the clinical utility of MBSR as an intervention for chronic inflammatory diseases such as UC. By so doing we would greatly improve our ability to help people with chronic diseases using this CAM approach.
描述(由申请人提供):本RO1项目的总体目标是开发和验证一套生物和心理特征(即生物生理标记)的“平台”,以预测和指示患者(Pt)对正念减压(MBSR)的反应,并验证量身定制的MBSR方法提高了MBSR对疾病结果的质量和一致性。我们的初步数据表明,只有一小部分溃疡性结肠炎(UC)患者对正念减压疗法有改善的疾病结果,这与文献报道正念减压疗法应用于其他疾病时类似的混合结果一致,表明某些生物标记物可能影响成功。因此,我们假设对正念减压疗法的不同反应是正念减压疗法开始时生物生理标志物个体差异的结果。当前提案的目标是确定和验证可预测的生物同步标记和可靠的可测量结果作为MBSR成功的决定因素。为实现这一目标,我们提出了两个具体目标。目的1:开发一套生物心理标志物,包括关键的心理和生物学特征,(a)预测UC Pt对MBSR的反应,(b)建立一套客观的标志物,证明MBSR对幸福感和UC疾病状态的影响。目的2:验证Pt和干预调整的影响,以确定(a)根据生物生理标志物调整Pt选择,以及(b)调整MBSR治疗方案是否会影响MBSR对UC患者炎症途径、疾病标志物和心理健康的影响。实现这些目标将建立一套客观的Pt特征,预测正念减压疗法的有效性,从而提高正念减压疗法作为一种治疗方法的质量和一致性。这将为MBSR治疗慢性炎症性疾病开辟新的创新治疗应用。

项目成果

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STEVAN HOBFOLL其他文献

STEVAN HOBFOLL的其他文献

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{{ truncateString('STEVAN HOBFOLL', 18)}}的其他基金

Research Training/Educaiton Core
研究培训/教育核心
  • 批准号:
    8356077
  • 财政年份:
    2012
  • 资助金额:
    $ 41.19万
  • 项目类别:
Biological & Psychological Factors as Predictors & Indicators of MBSR Response
生物
  • 批准号:
    8672599
  • 财政年份:
    2011
  • 资助金额:
    $ 41.19万
  • 项目类别:
Biological & Psychological Factors as Predictors & Indicators of MBSR Response
生物
  • 批准号:
    8321478
  • 财政年份:
    2011
  • 资助金额:
    $ 41.19万
  • 项目类别:
Biological & Psychological Factors as Predictors & Indicators of MBSR Response
生物
  • 批准号:
    8496498
  • 财政年份:
    2011
  • 资助金额:
    $ 41.19万
  • 项目类别:
Biological & Psychological Factors as Predictors & Indicators of MBSR Response
生物
  • 批准号:
    8848039
  • 财政年份:
    2011
  • 资助金额:
    $ 41.19万
  • 项目类别:
STRESS MEASURES/PSYCHOMETRICS
压力测量/心理测量
  • 批准号:
    7881326
  • 财政年份:
    2010
  • 资助金额:
    $ 41.19万
  • 项目类别:
Terrorism and Traumatic Responding: Exposure and Resiliency Factors
恐怖主义和创伤反应:暴露和复原力因素
  • 批准号:
    7689862
  • 财政年份:
    2006
  • 资助金额:
    $ 41.19万
  • 项目类别:
Terrorism and Traumatic Responding: Exposure and Resiliency Factors
恐怖主义和创伤反应:暴露和复原力因素
  • 批准号:
    7263144
  • 财政年份:
    2006
  • 资助金额:
    $ 41.19万
  • 项目类别:
Terrorism and Traumatic Responding: Exposure and Resiliency Factors
恐怖主义和创伤反应:暴露和复原力因素
  • 批准号:
    7497127
  • 财政年份:
    2006
  • 资助金额:
    $ 41.19万
  • 项目类别:
Terrorism and Traumatic Responding: Exposure and Resiliency Factors
恐怖主义和创伤反应:暴露和复原力因素
  • 批准号:
    7139454
  • 财政年份:
    2006
  • 资助金额:
    $ 41.19万
  • 项目类别:

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