Biological & Psychological Factors as Predictors & Indicators of MBSR Response

生物

• 批准号: 8321478
• 负责人: STEVAN HOBFOLL
• 金额: $ 45.1万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8321478
• 关键词: Address; Advocate; Agreement; Anxiety; Biologic Characteristic; Biological; Biological Factors; Characteristics; Chronic; Chronic Disease; Clinical; Clinical Research; Complementary and alternative medicine; Data; Disease; Disease Marker; Disease Outcome; Disease Progression; Effectiveness; Enrollment; Ensure; Flare; Funding; Goals; Health; Individual; Inflammation; Inflammatory; Inflammatory disease of the intestine; Injury; Intervention; Intestines; Lead; Life; Link; Literature; Manuals; Measurable; Measures; Mediating; Mind-Body Intervention; Modeling; Modification; National Center for Complementary and Alternative Medicine; Organ failure; Outcome; Outcome Measure; Pathway interactions; Patient Selection; Patients; Personal Satisfaction; Physiological; Process; Protocols documentation; Psychological Factors; Quality of life; Questionnaires; Randomized; Recruitment Activity; Relapse; Reporting; Selection for Treatments; Signal Pathway; Stress; Symptoms; Therapeutic; Tissues; Treatment Protocols; Ulcerative Colitis; base; biological adaptation to stress; body-mind; cohort; design; disease characteristic; improved; innovation; mindfulness; mindfulness-based stress reduction; prevent; psychologic; response; stressor; success; tool; trait

DESCRIPTION (provided by applicant): The overall goal of this RO1 project is to develop and validate a set "platform" of biological and psychological characteristics (i.e., biopsychomarkers) that predict and indicate patient (Pt) response to mindfulness-based stress reduction (MBSR) and verify that a tailored MBSR approach improves the quality and consistency of MBSR on disease outcomes. Our preliminary data demonstrate that only a subset of ulcerative colitis (UC) Pts respond to MBSR with improved disease outcomes which is in agreement with the literature which reports similar mixed outcomes with mindfulness therapy when it has been applied to other diseases, suggesting that certain biopsychomarkers may impact success. Thus, we hypothesize that the differential responses to MBSR are a consequence of individual variance in biopsychomarkers at the onset of MBSR therapy. The objective of the current proposal is then to identify and verify predictive biopsychomarkers and reliable measurable outcomes as determinants of MBSR success. To achieve this objective we propose two Specific Aims. Aim1: Develop a set of biopsychomarkers, comprised of key psychological and biological characteristics that (a) predict UC Pt response to MBSR and (b) establish an objective set of markers that demonstrate the impact of MBSR on well-being and UC disease state. Aim 2: Verify the impact of Pt and intervention tailoring in order to determine whether (a) tailoring Pt selection based on biopsychomarkers, and whether (b) tailoring of MBSR treatment protocol will impact MBSR's effects on inflammatory pathways and markers of disease and psychological well-being in UC Pts. Accomplishing these Aims will establish an objective set of Pt characteristics that predict effectiveness of MBSR resulting in increased quality and consistency of MBSR as a therapeutic approach. This should open new innovative therapeutic applications for MBSR for the treatment of chronic inflammatory diseases.

描述（由申请人提供）：该RO1项目的总体目标是开发和验证一个预测和表明患者（PT）对基于正念的压力减轻（MBSR）的反应的生物学和心理特征的“平台”（即生物心理标志物），并验证MBSR的量身定制的MBS可以改善MBSR质量和MBSR的质量和一致性。我们的初步数据表明，只有一部分溃疡性结肠炎（UC）PTS对MBSR有反应，并改善了疾病结局，这与文献一致，这些文献在将某些生物心理标记物应用于其他疾病时报告了与其他疾病的混合结局，这可能会影响成功。因此，我们假设对MBSR的差异反应是MBSR治疗开始时生物心理标志物中个体差异的结果。然后，当前建议的目的是识别和验证预测性生物心理标志物和可靠的可测量结果作为MBSR成功的决定因素。为了实现这一目标，我们提出了两个具体目标。 AIM1：开发一组由关键的心理和生物学特征组成的生物心理标志物，这些特征（a）预测UC PT对MBSR的反应，以及（b）建立一组客观的标记，这些标记表明MBSR对幸福感和UC疾病状态的影响。 AIM 2：验证PT和干预调整的影响，以确定（a）是否基于生物心理标志物来调整PT选择，以及（b）（b）定制MBSR治疗方案是否会影响MBSR对UC PT中疾病的炎症途径和心理健康的影响。实现这些目标将建立一组客观的PT特征，以预测MBSR的有效性，从而提高MBSR作为治疗方法的质量和一致性。这应该为MBSR开辟新的创新治疗应用，以治疗慢性炎症性疾病。