Emory WIHS CRS - Longitudinal Cohort

埃默里大学 WIHS CRS - 纵向队列

• 批准号: 8432684
• 负责人: Ighovwerha Ofotokun
• 金额: $ 240万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-01-15 至 2017-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8432684
• 关键词: AIDS clinical trial group; AIDS diagnosis; AIDS/HIV problem; Accounting; Acquired Immunodeficiency Syndrome; Adherence; Affect; Alabama; Anti-Retroviral Agents; Area; B-Lymphocyte Subsets; Behavioral; Behavioral Research; CD4 Positive T Lymphocytes; Cardiac; Caring; Cell Count; Cessation of life; Child; Clinic Visits; Clinical; Cohort Studies; Collaborations; Color; Colposcopy; Communities; Counseling; County; Data; Disadvantaged; Discipline; Disease; Disease Management; Drug Kinetics; Dual-Energy X-Ray Absorptiometry; Economics; Employee Strikes; Epidemic; Epidemiology; Faculty; Family; Female; Functional Magnetic Resonance Imaging; Genital system; Goals; HIV; HIV Infections; HIV Vaccine Trials Network; Harm Reduction; Health; Health Benefit; Health Services Accessibility; Healthcare; Highly Active Antiretroviral Therapy; Hispanics; Human immunodeficiency virus test; Immunologics; Incidence; Individual; Infection; Intervention; Life; Link; Maintenance; Measures; Memory; Minority Groups; Mission; Morbidity - disease rate; Mucosal Immunity; Newly Diagnosed; North Carolina; Outcome; Patients; Pharmaceutical Preparations; Prevention; Provider; Public Health; Recording of previous events; Recruitment Activity; Relative (related person); Research; Research Personnel; Research Proposals; Resources; Risk; Rural; Scientist; Secondary Prevention; Series; Serological; Site; Social Welfare; Specimen; Tennessee; Translational Research; Ultrasonography; Ursidae Family; Vision; Woman; Women' s Health; base; burden of illness; child bearing; clinical research site; cohort; community based participatory research; demographics; effective therapy; ethnic minority population; experience; improved; innovation; men; mortality; peripheral blood; public health relevance; repository; research study; social; statistics; success; therapy design; transmission process; treatment adherence; trend

DESCRIPTION (provided by applicant): Atlanta, due to the large size of its HIV epidemic, will serve as the ideal site to recruit HIV-infected and at-risk women who are representative of the Southern epidemic into the Women's Interagency Health Study (WIHS). Inclusion of Atlanta will expand the WIHS research expertise and agenda to include areas for which the Emory faculty are leading experts nationally. The potential of an Emory CRS is evident from the experience and excellent track record in the accrual of hundreds of women into HIV research including the DAIDS supported networks (ACTG, HPTN, HVTN) trials, and from the availability of state-of-the-art research capacity relevant to women's health (colposcopy, DXA and fMRI, carotid intima ultrasound, cardiac CT, local specimen repository, etc.). The size of our HIV clinical activities, which include 7,921 patients (22% women), 950 whom are newly diagnosed and antiretroviral treatment naive, offers a unique opportunity to diversify the WIHS cohort. Through long-standing collaboration between Emory investigators, county health departments, and community based organizations in the state, the Emory WIHS CRS will attract eligible subjects from rural Georgia and from the hard-to-reach communities to better characterize the changing demographics of the epidemic in the South. Innovative approaches guided by principles aligned with community-based participatory research will be employed to recruit, link, and retain women in the WIHS cohort. The overarching focus of the Emory WIHS application is "HIV/AIDS secondary prevention for women through immunological, clinical, pharmacological, epidemiological and behavioral research." Our vision is to make major contributions in effective behavioral and clinical interventions, and explore immunologic, epidemiological and pharmacological activities confronting women living with HIV. This vision is operationalized in our multisite research proposal "The Emory SWEET Trial," an innovative implementable smartphone intervention designed to enhance antiretroviral adherence, promote harm reduction, reduce STDs incidence, and improve overall clinical and biomedical outcomes among HIV-infected and at-risk women. The site-specific projects engage the expertise of leading scientists at Emory to explore using the local WIHS cohort, the intracellular pharmacokinetics of commonly used antiretroviral drugs in HAART and PrEP, define the dyadic features that impact the lives of women living with HIV through couple voluntary counseling and HIV testing, and examine B cell subsets, PD- 1 expression, and serologic memory in peripheral blood and the female genital tract of HIV-infected women, to better characterize the impact of HIV infection on genital mucosal immunity.

描述（由申请人提供）：由于艾滋病毒流行规模较大，亚特兰大将成为招募代表南方流行病的艾滋病毒感染者和高危妇女参加妇女机构间健康研究 (WIHS) 的理想场所。亚特兰大的加入将扩大 WIHS 的研究专业知识和议程，以涵盖埃默里大学教师在全国领先的领域。埃默里大学 CRS 的潜力显而易见，包括数百名妇女参与艾滋病毒研究（包括 DAIDS 支持的网络（ACTG、HPTN、HVTN）试验）的经验和良好记录，以及与妇女健康相关的最先进的研究能力（阴道镜检查、DXA 和功能磁共振成像、颈动脉内膜超声、心脏 CT、局部标本库等）。我们的 HIV 临床活动规模包括 7,921 名患者（22% 为女性），其中 950 名是新诊断且未接受过抗逆转录病毒治疗的患者，这为 WIHS 队列的多样化提供了独特的机会。通过埃默里大学调查人员、县卫生部门和该州社区组织之间的长期合作，埃默里大学 WIHS CRS 将吸引来自佐治亚州农村和难以到达的社区的合格受试者，以更好地描述南部流行病的人口统计特征。将采用以与基于社区的参与性研究相一致的原则为指导的创新方法来招募、联系和留住 WIHS 队列中的女性。埃默里大学 WIHS 应用程序的首要重点是“通过免疫学、临床、药理学、流行病学和行为研究对女性进行艾滋病毒/艾滋病二级预防”。我们的愿景是在有效的行为和临床干预方面做出重大贡献，并探索艾滋病毒感染女性面临的免疫学、流行病学和药理学活动。这一愿景在我们的多站点研究计划“埃默里 SWEET 试验”中得以实施，这是一项创新的、可实施的智能手机干预措施，旨在提高抗逆转录病毒治疗的依从性，促进减少危害，减少性传播疾病的发病率，并改善艾滋病毒感染者和高危女性的整体临床和生物医学结果。这些特定地点的项目利用埃默里大学领先科学家的专业知识，利用当地 WIHS 队列探索 HAART 和 PrEP 中常用抗逆转录病毒药物的细胞内药代动力学，通过夫妇自愿咨询和 HIV 检测确定影响 HIV 感染女性生活的二元特征，并检查外周血和女性生殖器中的 B 细胞亚群、PD-1 表达和血清学记忆 艾滋病毒感染妇女的道，以更好地表征艾滋病毒感染对生殖器粘膜免疫的影响。