Los Angeles - Southern California NINDS Stroke Trial Network (LASC NSTN)

描述(申请人提供)：中风是美国第四大致死原因，也是致残的主要原因。有效地开发预防中风、急性治疗和康复的新疗法是当务之急。这项申请是为了形成一个洛杉矶-南加州地区协调中心(LASC RCC)，该中心将在洛杉矶和奥兰治县组织一个由49个急性中风和康复医疗中心组成的网络，以高效和出色地执行5-10个NINDS中风临床试验网络预防、急性和康复临床试验。参与该网络的医院包括7家ACADIC和33家学术-社区和社区混合医疗中心。在特定神经血管研究领域具有专门知识的12个工作组将促进网络内的试验实施，并作为RCC领导层和个别绩效地点的资源。这项建议的四个具体目标是：1)在洛杉矶县和奥兰治县进行高质量的NINDS卒中临床试验(NSTN)急性和预防试验；2)在洛杉矶和奥兰治县进行高质量的NSTN康复和康复试验；3)确保大量未得到充分服务的人群参与NSTN试验，包括妇女、西班牙裔美国人、非裔美国人和其他少数群体；以及4)教育研究员、住院医生、医学生、医学预科生和初级教员从事中风的翻译研究。

DESCRIPTION (provided by applicant): Stroke is the 4th leading cause of death and a leading cause of disability in the United States. It is imperative that new treatments for stroke prevention, acute therapy, and recovery be efficiently developed. This application is to form a Los Angeles - Southern California Regional Coordinating Center (LASC RCC) that will marshal a network of 49 acute stroke and rehabilitation medical centers in Los Angeles and Orange Counties, to perform 5-10 NINDS Stroke Clinical Trial Network prevention, acute, and recovery clinical trials efficiently and excellently. Participating hospitals in the network include 7 acadeic and 33 mixed academic-community and community medical centers. Twelve Working Groups with expertise in specific neurovascular research domains will facilitate trial implementation within the Network and serve as a resource to the RCC leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high quality NINDS Stroke Clinical Trial (NSTN) acute and prevention trials throughout Los Angeles and Orange Counties; 2) perform high quality NSTN recovery and rehabilitation trials throughout Los Angeles and Orange Counties; 3) ensure participation of high volumes of underserved populations in NSTN trials, including women, Hispanic-American, African- American, and other minority populations; and 4) educate fellows, residents, medical students, premedical students, and junior faculty to engage in stroke translational research.