Los Angeles - Southern California NINDS Stroke Trial Network (LASC NSTN)

洛杉矶 - 南加州 NINDS 中风试验网络 (LASC NSTN)

基本信息

批准号：
8662444
负责人：
JEFFREY L SAVER
金额：
$ 41.11万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8662444
关键词：
Academic Medical Centers Accident and Emergency department Achievement Acute Address Adherence Adult African American Aging American Biological Markers Blood Vessels California Caring Cause of Death Cerebrovascular Disorders Child Clinical Research Clinical Trials Clinical Trials Network Collaborations Communities County Disease Emergency Medicine Emergency Situation Employee Strikes Ensure Environment Faculty Goals Grant Hispanic Americans Hospitals Individual Inpatients Intervention Lead Leadership Los Angeles Marshal Medical Medical Students Medical center Mentors Minority Multi-Institutional Clinical Trial National Institute of Neurological Disorders and Stroke Neurologist Neurology Neurosurgeon Nurses Oranges Outcome Measure Paramedical Personnel Patient Dropouts Patient Noncompliance Patients Pediatric Hospitals Performance Phase Physical Medicine Physicians Population Premedical Students Prevention Principal Investigator Randomized Clinical Trials Recovery Rehabilitation Centers Rehabilitation therapy Research Research Infrastructure Research Personnel Resources Self Perception Staging Stroke Stroke prevention System Time Training Translational Research Underserved Population United States Woman acute stroke arm career cerebrovascular decision-making capacity disability experience follow-up implementation trial neurosurgery novel outreach performance site programs public health relevance safety net stroke recovery stroke rehabilitation success validation studies working group

项目摘要

DESCRIPTION (provided by applicant): Stroke is the 4th leading cause of death and a leading cause of disability in the United States. It is imperative that new treatments for stroke prevention, acute therapy, and recovery be efficiently developed. This application is to form a Los Angeles - Southern California Regional Coordinating Center (LASC RCC) that will marshal a network of 49 acute stroke and rehabilitation medical centers in Los Angeles and Orange Counties, to perform 5-10 NINDS Stroke Clinical Trial Network prevention, acute, and recovery clinical trials efficiently and excellently. Participating hospitals in the network include 7 acadeic and 33 mixed academic-community and community medical centers. Twelve Working Groups with expertise in specific neurovascular research domains will facilitate trial implementation within the Network and serve as a resource to the RCC leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high quality NINDS Stroke Clinical Trial (NSTN) acute and prevention trials throughout Los Angeles and Orange Counties; 2) perform high quality NSTN recovery and rehabilitation trials throughout Los Angeles and Orange Counties; 3) ensure participation of high volumes of underserved populations in NSTN trials, including women, Hispanic-American, African- American, and other minority populations; and 4) educate fellows, residents, medical students, premedical students, and junior faculty to engage in stroke translational research.

描述（由申请人提供）：中风是美国第四主要死亡原因，也是美国残疾的主要原因。必须有效发展用于预防中风，急性治疗和恢复的新治疗方法。该应用程序是组成洛杉矶 - 南加州地区协调中心（LASC RCC），该中心将在洛杉矶和橙色县组成49个急性中风和康复医疗中心，以进行5-10个Ninds Streos Stroke临床试验网络预防，急性和恢复临床试验，并有效地进行了康复临床试验。参与网络的医院包括7个Acadeic和33个混合学术社区和社区医疗中心。在特定神经血管研究领域具有专业知识的12个工作组将有助于网络内的试验实施，并作为RCC领导力和个人性能站点的资源。该提案的四个具体目的是：1）整个洛杉矶和橙色县进行高质量的Ninds中风临床试验（NSTN）急性和预防试验； 2）在洛杉矶和橙色县进行高质量的NSTN恢复和康复试验； 3）确保参与大量服务不足的人群参加NSTN试验，包括妇女，西班牙裔美国人，非裔美国人和其他少数民族； 4）教育研究员，居民，医学生，预科学生和初级教师从事中风翻译研究。