Los Angeles - Southern California (LASC) NIH StrokeNet Regional Coordinating Center

中风是南加州的第二大死亡原因，也是导致残疾的主要原因。是 迫切需要有效地开发用于中风预防、急性治疗和康复的新疗法。 本申请旨在更新NIH洛杉矶-南加州StrokeNet区域协调 中心（LASC StrokeNet RCC），该中心汇集了37个急性卒中和康复医疗中心， 洛杉矶和橙子县，以及新墨西哥州，将在 预防，急性，恢复，高效，卓越。参与网络的医院包括7家 学术和30个混合学术社区和社区医疗中心。12 LASC StrokeNet 具有特定神经血管研究领域专业知识的工作组促进了 网络，并作为资源，以RCC领导和个别的性能网站。 该提案的四个具体目标是：1）执行高质量的NIH StrokeNet急性和 整个洛杉矶和橙子县以及新墨西哥州的预防试验; 2）执行高质量的NIH 在整个洛杉矶、橙子县和新墨西哥州开展StrokeNet恢复和康复试验; 3） 确保大量服务不足的人群参与NIH StrokeNet试验，包括女性， 西班牙裔美国人，非洲裔美国人，和其他少数民族人口;和4）教育研究员，居民， 医学生、医学预科生和初级教师从事中风转化研究。

Stroke is the 2nd leading cause of death and a leading cause of disability in Southern California. It is imperative that new treatments for stroke prevention, acute therapy, and recovery be efficiently developed. This application is to renew the NIH Los Angeles – Southern California StrokeNet Regional Coordinating Center (LASC StrokeNet RCC) that marshals a network of 37 acute stroke and rehabilitation medical centers in Los Angeles and Orange Counties, and New Mexico, which will perform 5-10 NIH StrokeNet trials in prevention, acute, and recovery, efficiently and excellently. Participating hospitals in the network include 7 academic and 30 mixed academic-community and community medical centers. Twelve LASC StrokeNet Working Groups with expertise in specific neurovascular research domains facilitate trial implementation within the Network and serve as a resource to the RCC leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high quality NIH StrokeNet acute and prevention trials throughout Los Angeles and Orange Counties, and New Mexico; 2) perform high quality NIH StrokeNet recovery and rehabilitaiton trials throughout Los Angeles and Orange Counties, and New Mexico; 3) ensure participation of high volumes of underserved populations in NIH StrokeNet trials, including women, Hispanic-American, African-American, and other minority populations; and 4) educate fellows, residents, medical students, premedical students, and junior faculty to engage in stroke translational research.