Los Angeles Neurological Emergencies Treatment Trials (LA NETT)

描述（由申请人提供）：神经急救试验需要大量的基础设施，院前、急诊科和住院神经病学/神经外科系统之间的密切合作，以及一个由医生、护士和护理人员组成的专门小组，随时准备投入时间和资源以确保试验成功。这些情况突然发生，需要在院前或急诊室环境中立即干预，并损害受影响个体的自我意识和决策能力。拟议的洛杉矶神经系统紧急情况治疗试验中心和辐条网络将美国最大和最多样化的县的29家EMS提供机构和38家专科接收医院组成的联盟聚集在一起，形成一个中心和辐条网络，旨在以高招募率和高质量的数据收集和监测进行3期NETT试验。 该提案的4个目标是：1）在洛杉矶县的几种不同类型的影响成人或儿童的紧急神经系统疾病中进行高质量的NETT临床试验; 2）促进洛杉矶县的急诊医学医生与神经和神经外科疾病专家在试验设计和执行方面的合作; 3）促进院前EMS系统与急性接收医院之间的合作，包括整个洛杉矶县的创伤、中风和心脏复苏专业接收中心在试验设计和执行方面的合作; 4）确保大量神经系统急症患者参与NETT临床试验，包括女性、西班牙裔美国人、非洲裔美国人和其他少数民族。

DESCRIPTION (provided by applicant): Neuroemergency trials require substantial infrastructure, close collaboration between pre-hospital, Emergency Department, and inpatient neurology/neurosurgery systems, and a dedicated group of physician, nurse, and paramedic researchers ready to invest time and resources to ensure trial success. These conditions strike suddenly, require immediate intervention in the pre-hospital or Emergency Department setting, and impair the self-awareness and decision-making capacity of the afflicted individual. The proposed Los Angeles Neurological Emergencies Treatment Trials Hub and Spoke Network brings together a consortium of 29 EMS Provider Agencies and 38 specialty receiving hospitals in the country's largest and most diverse County in a Hub and Spoke network designed to perform phase 3 NETT trials with high rates if recruitment and high quality of data collection and monitoring. The 4 aims of this proposal are to: 1) Perform high-quality NETT clinical trials in several different types of emergency neurological disorders afflicting adults or children throughout Los Angeles County; 2) Facilitate collaboration between emergency medicine physicians and neurological and neurosurgical disease specialists throughout Los Angeles County in trial design and execution; 3) Facilitate collaboration between the pre-hospital EMS system and acute receiving hospitals, including specialty receiving centers in trauma, stroke, and cardiac resuscitation, throughout Los Angeles County in trial design and execution; and 4) Ensure participation of a substantial number of patients with neurologic emergencies in NETT clinical trials, including women, Hispanic-Americans, African-Americans, and other minority populations.