Los Angeles Neurological Emergencies Treatment Trials (LA NETT)

洛杉矶神经紧急情况治疗试验 (LA NetT)

基本信息

批准号：
8536972
负责人：
JEFFREY L SAVER
金额：
$ 24.28万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-01 至 2017-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8536972
关键词：
Accident and Emergency department Achievement Acute Adult Affect African American Ambulances Anoxic Encephalopathy Award Bacterial Meningitis Cardiac Caring Cause of Death Cerebral hemisphere hemorrhage Cessation of life Child Clinical Trials Clinical Trials Design Collaborations Country County Data Collection Data Quality Disease Emergency Medicine Emergency Situation Emergency treatment Employee Strikes Ensure Goals Hispanic Americans Hospital Departments Hospitals Individual Inpatients Intervention Ischemic Stroke Knowledge Los Angeles Magnesium Minority Monitor National Institute of Neurological Disorders and Stroke Nervous system structure Neurologic Neurological emergencies Neurologist Neurology Neurosurgeon Nurses Paramedical Personnel Patients Phase Phase III Clinical Trials Physicians Population Provider Research Research Infrastructure Research Personnel Resources Resuscitation Self Perception Specialist Spinal cord injury Status Epilepticus Stroke System Time Trauma Traumatic Brain Injury United States United States National Institutes of Health Woman care systems clinical practice decision-making capacity design disability medical specialties meetings nervous system disorder neurosurgery outreach public health relevance relating to nervous system stroke therapy success treatment trial

项目摘要

DESCRIPTION (provided by applicant): Neuroemergency trials require substantial infrastructure, close collaboration between pre-hospital, Emergency Department, and inpatient neurology/neurosurgery systems, and a dedicated group of physician, nurse, and paramedic researchers ready to invest time and resources to ensure trial success. These conditions strike suddenly, require immediate intervention in the pre-hospital or Emergency Department setting, and impair the self-awareness and decision-making capacity of the afflicted individual. The proposed Los Angeles Neurological Emergencies Treatment Trials Hub and Spoke Network brings together a consortium of 29 EMS Provider Agencies and 38 specialty receiving hospitals in the country's largest and most diverse County in a Hub and Spoke network designed to perform phase 3 NETT trials with high rates if recruitment and high quality of data collection and monitoring. The 4 aims of this proposal are to: 1) Perform high-quality NETT clinical trials in several different types of emergency neurological disorders afflicting adults or children throughout Los Angeles County; 2) Facilitate collaboration between emergency medicine physicians and neurological and neurosurgical disease specialists throughout Los Angeles County in trial design and execution; 3) Facilitate collaboration between the pre-hospital EMS system and acute receiving hospitals, including specialty receiving centers in trauma, stroke, and cardiac resuscitation, throughout Los Angeles County in trial design and execution; and 4) Ensure participation of a substantial number of patients with neurologic emergencies in NETT clinical trials, including women, Hispanic-Americans, African-Americans, and other minority populations.

描述（由申请人提供）：神经递观试验需要大量基础设施，院前，急诊科和住院神经病学/神经外科手术系统之间的密切合作，以及一组专门的医师，护士和护理人员研究人员，准备投入时间和资源，以确保试验成功。这些条件突然袭来，需要立即干预院前或急诊部门的设置，并损害受苦个人的自我意识和决策能力。拟议的洛杉矶神经紧急情况治疗试验HUB和Skoke Network汇集了一个由29个EMS提供商机构组成的联盟，以及该国最大，最多样化的县的38家专业接收医院，旨在执行3阶段的NetT试验，如果招募和高质量的数据收集质量，则进行3阶段的NetT试验。该提案的4个目标是：1）在多种类型的紧急神经系统疾病中进行高质量的NetT临床试验。 2）促进急诊医学医生与洛杉矶县的神经和神经外科疾病专家之间的合作，以试验设计和执行； 3）促进院前EMS系统与急性接收医院之间的合作，包括在整个洛杉矶县的创伤，中风和心脏复苏的专业接收中心，以试验设计和执行； 4）确保参加大量神经系统紧急情况的患者参与NETT临床试验，包括妇女，西班牙裔美国人，非裔美国人和其他少数群体。