Los Angeles Neurological Emergencies Treatment Trials (LA NETT)

洛杉矶神经紧急情况治疗试验 (LA NetT)

• 批准号: 8726501
• 负责人: JEFFREY L SAVER
• 金额: $ 24.28万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8726501
• 关键词: Accident and Emergency department; Achievement; Acute; Adult; Affect; African American; Ambulances; Anoxic Encephalopathy; Award; Bacterial Meningitis; Cardiac; Caring; Cause of Death; Cerebral hemisphere hemorrhage; Cessation of life; Child; Clinical Trials; Clinical Trials Design; Collaborations; Country; County; Data Collection; Data Quality; Disease; Emergency Department Physician; Emergency Medicine; Emergency Situation; Emergency treatment; Employee Strikes; Ensure; Goals; Hispanic Americans; Hospital Departments; Hospitals; Individual; Inpatients; Intervention; Ischemic Stroke; Knowledge; Los Angeles; Magnesium; Minority; Monitor; National Institute of Neurological Disorders and Stroke; Nervous system structure; Neurologic; Neurological emergencies; Neurologist; Neurology; Neurosurgeon; Nurses; Paramedical Personnel; Patients; Phase; Phase III Clinical Trials; Physicians; Population; Provider; Research; Research Infrastructure; Research Personnel; Resources; Resuscitation; Self Perception; Specialist; Spinal cord injury; Status Epilepticus; Stroke; System; Time; Trauma; Traumatic Brain Injury; United States; United States National Institutes of Health; Woman; care systems; clinical practice; decision-making capacity; design; disability; medical specialties; meetings; nervous system disorder; neurosurgery; outreach; public health relevance; relating to nervous system; stroke therapy; success; treatment trial

DESCRIPTION (provided by applicant): Neuroemergency trials require substantial infrastructure, close collaboration between pre-hospital, Emergency Department, and inpatient neurology/neurosurgery systems, and a dedicated group of physician, nurse, and paramedic researchers ready to invest time and resources to ensure trial success. These conditions strike suddenly, require immediate intervention in the pre-hospital or Emergency Department setting, and impair the self-awareness and decision-making capacity of the afflicted individual. The proposed Los Angeles Neurological Emergencies Treatment Trials Hub and Spoke Network brings together a consortium of 29 EMS Provider Agencies and 38 specialty receiving hospitals in the country's largest and most diverse County in a Hub and Spoke network designed to perform phase 3 NETT trials with high rates if recruitment and high quality of data collection and monitoring. The 4 aims of this proposal are to: 1) Perform high-quality NETT clinical trials in several different types of emergency neurological disorders afflicting adults or children throughout Los Angeles County; 2) Facilitate collaboration between emergency medicine physicians and neurological and neurosurgical disease specialists throughout Los Angeles County in trial design and execution; 3) Facilitate collaboration between the pre-hospital EMS system and acute receiving hospitals, including specialty receiving centers in trauma, stroke, and cardiac resuscitation, throughout Los Angeles County in trial design and execution; and 4) Ensure participation of a substantial number of patients with neurologic emergencies in NETT clinical trials, including women, Hispanic-Americans, African-Americans, and other minority populations.

描述（由申请人提供）：神经急诊试验需要大量的基础设施，院前、急诊科和住院神经内科/神经外科系统之间的密切合作，以及由医生、护士和护理研究人员组成的专门小组，准备好投入时间和资源以确保试验成功。这些情况突然发生，需要在院前或急诊科立即进行干预，并损害患者的自我意识和决策能力。拟议的洛杉矶神经急症治疗试验中心辐射网络将全国最大、最多样化的县的 29 家 EMS 提供机构和 38 家专科接收医院组成的联盟聚集在一个中心辐射网络中，旨在以高招募率和高质量的数据收集和监测来执行 3 期 NTT 试验。 该提案的 4 个目标是： 1) 针对洛杉矶县成人或儿童的几种不同类型的紧急神经系统疾病进行高质量的 NETT 临床试验； 2) 促进整个洛杉矶县的急诊科医生与神经病学和神经外科疾病专家在试验设计和执行方面的合作； 3) 促进院前 EMS 系统与整个洛杉矶县的急症接收医院（包括创伤、中风和心脏复苏专业接收中心）之间在试验设计和执行方面的合作； 4) 确保大量神经急症患者参与 NTT 临床试验，包括女性、西班牙裔美国人、非裔美国人和其他少数族裔。