Los Angeles - Southern California NINDS Stroke Trial Network (LASC NSTN)

洛杉矶 - 南加州 NINDS 中风试验网络 (LASC NSTN)

• 批准号: 8739691
• 负责人: JEFFREY L SAVER
• 金额: $ 39.82万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8739691
• 关键词: Academic Medical Centers; Accident and Emergency department; Achievement; Acute; Address; Adherence; Adult; African American; Aging; American; Biological Markers; Blood Vessels; California; Caring; Cause of Death; Cerebrovascular Disorders; Child; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communities; County; Disease; Emergency Department Physician; Emergency Medicine; Employee Strikes; Ensure; Environment; Faculty; Goals; Grant; Hispanic Americans; Hospitals; Individual; Inpatients; Intervention; Lead; Leadership; Los Angeles; Marshal; Medical; Medical Students; Medical center; Mentors; Minority; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Neurologist; Neurology; Neurosurgeon; Nurses; Oranges; Outcome Measure; Paramedical Personnel; Patient Dropouts; Patient Noncompliance; Patients; Pediatric Hospitals; Performance; Phase; Physical Medicine; Physical Rehabilitation; Physicians; Population; Premedical Students; Prevention; Principal Investigator; Randomized Clinical Trials; Recovery; Rehabilitation Centers; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Resources; Self Perception; Staging; Stroke; Stroke prevention; System; Time; Training; Translational Research; Underserved Population; United States; Woman; acute stroke; arm; career; cerebrovascular; decision-making capacity; disability; experience; follow-up; implementation trial; neurosurgery; novel; outreach; performance site; programs; public health relevance; safety net; stroke recovery; stroke rehabilitation; success; validation studies; working group

DESCRIPTION (provided by applicant): Stroke is the 4th leading cause of death and a leading cause of disability in the United States. It is imperative that new treatments for stroke prevention, acute therapy, and recovery be efficiently developed. This application is to form a Los Angeles - Southern California Regional Coordinating Center (LASC RCC) that will marshal a network of 49 acute stroke and rehabilitation medical centers in Los Angeles and Orange Counties, to perform 5-10 NINDS Stroke Clinical Trial Network prevention, acute, and recovery clinical trials efficiently and excellently. Participating hospitals in the network include 7 acadeic and 33 mixed academic-community and community medical centers. Twelve Working Groups with expertise in specific neurovascular research domains will facilitate trial implementation within the Network and serve as a resource to the RCC leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high quality NINDS Stroke Clinical Trial (NSTN) acute and prevention trials throughout Los Angeles and Orange Counties; 2) perform high quality NSTN recovery and rehabilitation trials throughout Los Angeles and Orange Counties; 3) ensure participation of high volumes of underserved populations in NSTN trials, including women, Hispanic-American, African- American, and other minority populations; and 4) educate fellows, residents, medical students, premedical students, and junior faculty to engage in stroke translational research.

描述（由申请人提供）：中风是美国第四大死亡原因和残疾的主要原因。当务之急是有效地开发用于中风预防、急性治疗和康复的新疗法。本申请旨在组建一个洛杉矶-南加州区域协调中心（LASC RCC），该中心将在洛杉矶和橙子县组建一个由49个急性卒中和康复医疗中心组成的网络，以高效、出色地开展5-10项NINDS卒中临床试验网络预防、急性和康复临床试验。参与该网络的医院包括7个社区医疗中心和33个混合学术社区和社区医疗中心。在特定神经血管研究领域具有专业知识的12个工作组将促进网络内的试验实施，并作为RCC领导层和各个性能站点的资源。 本提案的四个具体目标是：1）在洛杉矶和奥兰治县开展高质量的NINDS卒中临床试验（NINDS）急性和预防试验; 2）在洛杉矶和橙子县开展高质量的NINDS恢复和康复试验; 3）确保大量服务不足的人群参与NATIONAL试验，包括女性、西班牙裔美国人、非洲裔美国人，和其他少数民族人口;和4）教育研究员，居民，医学生，医学预科生，和初级教师从事中风转化研究。