Los Angeles - Southern California NINDS Stroke Trial Network (LASC NSTN)

洛杉矶 - 南加州 NINDS 中风试验网络 (LASC NSTN)

• 批准号: 8739691
• 负责人: JEFFREY L SAVER
• 金额: $ 39.82万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-30 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8739691
• 关键词: Academic Medical Centers; Accident and Emergency department; Achievement; Acute; Address; Adherence; Adult; African American; Aging; American; Biological Markers; Blood Vessels; California; Caring; Cause of Death; Cerebrovascular Disorders; Child; Clinical Research; Clinical Trials; Clinical Trials Network; Collaborations; Communities; County; Disease; Emergency Department Physician; Emergency Medicine; Employee Strikes; Ensure; Environment; Faculty; Goals; Grant; Hispanic Americans; Hospitals; Individual; Inpatients; Intervention; Lead; Leadership; Los Angeles; Marshal; Medical; Medical Students; Medical center; Mentors; Minority; Multi-Institutional Clinical Trial; National Institute of Neurological Disorders and Stroke; Neurologist; Neurology; Neurosurgeon; Nurses; Oranges; Outcome Measure; Paramedical Personnel; Patient Dropouts; Patient Noncompliance; Patients; Pediatric Hospitals; Performance; Phase; Physical Medicine; Physical Rehabilitation; Physicians; Population; Premedical Students; Prevention; Principal Investigator; Randomized Clinical Trials; Recovery; Rehabilitation Centers; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Resources; Self Perception; Staging; Stroke; Stroke prevention; System; Time; Training; Translational Research; Underserved Population; United States; Woman; acute stroke; arm; career; cerebrovascular; decision-making capacity; disability; experience; follow-up; implementation trial; neurosurgery; novel; outreach; performance site; programs; public health relevance; safety net; stroke recovery; stroke rehabilitation; success; validation studies; working group

DESCRIPTION (provided by applicant): Stroke is the 4th leading cause of death and a leading cause of disability in the United States. It is imperative that new treatments for stroke prevention, acute therapy, and recovery be efficiently developed. This application is to form a Los Angeles - Southern California Regional Coordinating Center (LASC RCC) that will marshal a network of 49 acute stroke and rehabilitation medical centers in Los Angeles and Orange Counties, to perform 5-10 NINDS Stroke Clinical Trial Network prevention, acute, and recovery clinical trials efficiently and excellently. Participating hospitals in the network include 7 acadeic and 33 mixed academic-community and community medical centers. Twelve Working Groups with expertise in specific neurovascular research domains will facilitate trial implementation within the Network and serve as a resource to the RCC leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high quality NINDS Stroke Clinical Trial (NSTN) acute and prevention trials throughout Los Angeles and Orange Counties; 2) perform high quality NSTN recovery and rehabilitation trials throughout Los Angeles and Orange Counties; 3) ensure participation of high volumes of underserved populations in NSTN trials, including women, Hispanic-American, African- American, and other minority populations; and 4) educate fellows, residents, medical students, premedical students, and junior faculty to engage in stroke translational research.

描述（由申请人提供）：中风是美国第四大死亡原因和致残原因。必须有效地开发新的中风预防、急性治疗和康复治疗方法。该申请是为了组建洛杉矶-南加州区域协调中心（LASC RCC），该中心将在洛杉矶和奥兰治县组织49个急性中风和康复医疗中心的网络，高效、出色地开展5-10个NINDS中风临床试验网络预防、急性和康复临床试验。参与网络的医院包括7个学术社区和33个混合学术社区和社区医疗中心。12个在特定神经血管研究领域具有专门知识的工作组将促进网络内的试验实施，并作为RCC领导层和个别表演场地的资源。该提案的四个具体目标是：1)在洛杉矶和奥兰治县开展高质量的NINDS卒中临床试验（NSTN）急性和预防试验；2)在洛杉矶和奥兰治县开展高质量的NSTN恢复和康复试验；3)确保大量服务不足的人群参与NSTN试验，包括妇女、西班牙裔美国人、非洲裔美国人和其他少数群体；4)教育研究员、住院医师、医学生、医预科生和初级教师从事卒中转化研究。