Southern California Network Clinical Center (Hub) for SIREN Emergency Care Clinical Trails

SIREN 紧急护理临床试验南加州网络临床中心（中心）

• 批准号: 9284308
• 负责人: JEFFREY L SAVER
• 金额: $ 25.71万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2022-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9284308
• 关键词: Academic Medical Centers; Accident and Emergency department; Acute; Adult; Affect; African American; Ambulances; American; Area; Brain; California; Cardiac; Cardiopulmonary Arrest; Caring; Cessation of life; Child; Clinical; Clinical Trials; Clinical Trials Network; Collaborations; County; Data Quality; Diagnosis; Discipline; Disease; Emergency Care; Emergency Department Physician; Emergency Medicine; Emergency Situation; Emergency research; Emergency treatment; Employee Strikes; Ensure; Event; Goals; Heart failure; Hematologist; Hemorrhagic Shock; Hispanic Americans; Hospitalists; Hospitals; Impairment; Individual; Injury; Inpatients; Interdisciplinary Study; Intervention; Knowledge; Lead; Leadership; Life; Los Angeles; Magnesium; Marshal; Medical; Medical center; Medicine; Multi-Institutional Clinical Trial; Myocardial Ischemia; Nervous System Trauma; Nervous system structure; Neurologic; Neurological emergencies; Neurologist; Neurosurgeon; Nurses; Operative Surgical Procedures; Oranges; Paramedical Personnel; Patient-Focused Outcomes; Patients; Personnel Staffing; Physicians; Population; Pragmatic clinical trial; Provider; Pulmonary Embolism; Recovery; Research; Research Infrastructure; Research Personnel; Research Training; Resources; Resuscitation; Self Perception; Specialist; Status Epilepticus; Stroke; System; Time; Time Study; Trauma; Underrepresented Populations; United States; United States National Institutes of Health; Woman; care systems; clinical care; clinical practice; decision-making capacity; disability; experience; flexibility; improved outcome; innovation; medical specialties; meetings; novel strategies; outreach; patient population; performance site; respiratory; stroke therapy; success; translational study; treatment trial; trial design

Medical and traumatic emergency conditions affecting the cardiac, respiratory, nervous, and hematologic systems collectively account for the overwhelming preponderance of death and disability affecting Americans. It is imperative that new approaches for timely diagnosis and treatment of these conditions treatments be efficiently developed. This application is to form a Southern California Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SoCal SIREN) Hub and Spoke system that will conduct high-quality, multi-site clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, and hematologic, and trauma emergency events. The SoCal SIREN consortium will marshal all six academic medical centers in the region (UCLA, Harbor-UCLA, USC, UCI, UCSD, and Cedars-Sinai); all 3 County EMS agencies [Los Angeles EMS (lead), Orange County EMS (co-lead), and San Diego County EMS (flexible)], and up to 83 potential performance sites (1 Hub, 5 Core Spoke, 16 Additional Spoke, and 61 Flexible Spoke) Medical Centers in Southern California, experienced in performing emergency clinical trials efficiently and excellently. Eleven Advisory Panels with expertise in specific disease and research domains will facilitate trial implementation within the Network and serve as a resource to the Hub leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high-quality pragmatic clinical trials in several different types of emergency disorders afflicting adults or children throughout Southern California; 2) facilitate collaboration between emergency medicine physicians and disease specialists throughout Southern California in trial design and execution high quality NSTN recovery and rehabilitaiton trials throughout Los Angeles and Orange Counties; 3) facilitate collaboration between the prehospital EMS system and acute receiving hospitals, including specialty receiving centers in trauma, stroke, and cardiac resuscitation, throughout Southern California in trial design and execution; and 4) ensure participation of a substantial number of patients with emergency conditions in SIREN clinical trials, including women, children, Hispanic-Americans, African-Americans, and other traditionally underrepresented populations.

影响心脏、呼吸、神经和血液系统的医疗和创伤性紧急情况 共同造成了影响美国人的绝大多数死亡和残疾。当务之急是 及时诊断和治疗这些疾病的新方法将被有效地开发。 本申请旨在形成南加州EmeRgENcy护理临床试验创新战略 网络（SoCal SIREN）的中心和辐条系统，将进行高质量的，多地点的临床试验，以提高 发生神经系统、心脏、呼吸系统、血液系统和创伤紧急事件的患者的结局。南加州 SIREN联盟将集结该地区所有六个学术医疗中心（加州大学洛杉矶分校，港湾加州大学洛杉矶分校，南加州大学，加州大学CI， UCSD和Cedars-Sinai）;所有3个县EMS机构[洛杉矶EMS（牵头）、橙子县EMS（共同牵头）和San Diego County EMS（灵活）]，以及多达83个潜在的性能站点（1个中心、5个核心分支、16个附加分支，以及 南加州的61个Flexible Spoke）医疗中心，在开展紧急临床试验方面经验丰富 高效和出色地。11个具有特定疾病和研究领域专门知识的咨询小组将促进 在网络内进行试验性实施，并作为中心领导层和各个绩效站点的资源。 该提案的四个具体目标是：1）在几个不同的国家进行高质量的实用临床试验。 在整个南加州折磨成人或儿童的紧急疾病类型; 2）促进合作 在整个南加州的急诊医生和疾病专家之间进行试验设计， 在整个洛杉矶和橙子县执行高质量的NATURAL恢复和康复试验; 3）促进 院前EMS系统与急性接收医院之间的合作，包括 在整个南加州的试验设计和执行中，确保创伤、中风和心脏复苏;以及4）确保 包括女性在内的大量急诊患者参与SIREN临床试验， 儿童，西班牙裔美国人，非洲裔美国人和其他传统上代表性不足的人群。