Southern California Network Clinical Center (Hub) for SIREN Emergency Care Clinical Trails

SIREN 紧急护理临床试验南加州网络临床中心（中心）

• 批准号: 10626189
• 负责人: JEFFREY L SAVER
• 金额: $ 8.32万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-15 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10626189
• 关键词: Academic Medical Centers; Accident and Emergency department; Acute; Adult; Affect; African American population; Ambulances; American; Area; Brain; California; Cardiac; Cardiopulmonary Arrest; Cardiopulmonary Resuscitation; Cessation of life; Child; Clinical; Clinical Trials; Clinical Trials Network; Collaborations; County; Data; Diagnosis; Discipline; Disease; Emergency Care; Emergency Department Physician; Emergency Medicine; Emergency Situation; Emergency research; Emergency treatment; Ensure; Event; Goals; Heart failure; Hematologist; Hematology; Hemorrhagic Shock; Hispanic Americans; Hospitalists; Hospitals; Impairment; Individual; Infrastructure; Injury; Inpatients; Interdisciplinary Study; Intervention; Knowledge; Lead; Leadership; Life; Los Angeles; Magnesium; Marshal; Medical; Medical center; Medicine; Multi-Institutional Clinical Trial; Myocardial Ischemia; Nervous System Trauma; Nervous system structure; Neurologic; Neurological emergencies; Neurologist; Neurosurgeon; Nurses; Operative Surgical Procedures; Oranges; Paramedical Personnel; Patient-Focused Outcomes; Patients; Personnel Staffing; Physicians; Population; Pragmatic clinical trial; Provider; Pulmonary Embolism; Recovery; Research; Research Personnel; Research Training; Resources; Self Perception; Specialist; Status Epilepticus; Stroke; System; Time; Time Study; Trauma; Underrepresented Populations; United States; United States National Institutes of Health; Woman; acute care; care systems; clinical care; clinical center; clinical practice; decision-making capacity; disability; emergency settings; experience; flexibility; improved outcome; innovation; medical specialties; meetings; novel strategies; outreach; patient population; performance site; respiratory; stroke therapy; success; translational study; treatment trial; trial design

Medical and traumatic emergency conditions affecting the cardiac, respiratory, nervous, and hematologic systems collectively account for the overwhelming preponderance of death and disability affecting Americans. It is imperative that new approaches for timely diagnosis and treatment of these conditions treatments be efficiently developed. This application is to form a Southern California Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SoCal SIREN) Hub and Spoke system that will conduct high-quality, multi-site clinical trials to improve the outcomes for patients with neurologic, cardiac, respiratory, and hematologic, and trauma emergency events. The SoCal SIREN consortium will marshal all six academic medical centers in the region (UCLA, Harbor-UCLA, USC, UCI, UCSD, and Cedars-Sinai); all 3 County EMS agencies [Los Angeles EMS (lead), Orange County EMS (co-lead), and San Diego County EMS (flexible)], and up to 83 potential performance sites (1 Hub, 5 Core Spoke, 16 Additional Spoke, and 61 Flexible Spoke) Medical Centers in Southern California, experienced in performing emergency clinical trials efficiently and excellently. Eleven Advisory Panels with expertise in specific disease and research domains will facilitate trial implementation within the Network and serve as a resource to the Hub leadership and to individual performance sites. The four specific aims of this proposal are to: 1) perform high-quality pragmatic clinical trials in several different types of emergency disorders afflicting adults or children throughout Southern California; 2) facilitate collaboration between emergency medicine physicians and disease specialists throughout Southern California in trial design and execution high quality NSTN recovery and rehabilitaiton trials throughout Los Angeles and Orange Counties; 3) facilitate collaboration between the prehospital EMS system and acute receiving hospitals, including specialty receiving centers in trauma, stroke, and cardiac resuscitation, throughout Southern California in trial design and execution; and 4) ensure participation of a substantial number of patients with emergency conditions in SIREN clinical trials, including women, children, Hispanic-Americans, African-Americans, and other traditionally underrepresented populations.

影响心脏、呼吸、神经和血液系统的医疗和创伤性紧急情况