CORE 1 - Institutional Center Cores for Advanced Neuroimaging

CORE 1 - 高级神经影像机构中心核心

• 批准号: 8538133
• 负责人: KAMIL UGURBIL
• 金额: $ 17.54万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-30 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8538133
• 关键词: Animals; Blood; Blood specimen; Brain; Communities; Computer software; Development; Doctor of Philosophy; Engineering; Ensure; Funding; Goals; Human; Image; Infusion procedures; Magnetic Resonance Imaging; Methodology; Methods; National Institute of Neurological Disorders and Stroke; Neurosciences; Neurosciences Research; Noise; Performance; Physiologic pulse; Quality Control; RF coil; Research Infrastructure; Research Personnel; Research Project Grants; Resolution; Resources; Safety; Services; Signal Transduction; Source; Structure; System; Techniques; Tracer; Training; Venous; Work; data acquisition; imaging modality; instrument; instrumentation; magnetic field; multidisciplinary; neuroimaging; novel; reconstruction; translational neuroscience

1. HIGH AND ULTRAHIGH FIELD IMAGE ACQUISITION AND ENGINEERING PI: Pierre-Francois van de Moortlele, PhD Core Aims The long-term goal of this core is to provide the means to enhance, broaden and accelerate a large array of ambitious neuroscience research projects that are increasingly utilizing high (3 and 4T) and ultrahigh (7T and above) field MR Imaging instruments and novel image acquisition and reconstruction techniques to investigate brain structure and function. Multiple studies have now amply demonstrated that MRI at higher magnetic fields can provide significant advantages in signal-to-noise ratio (SNR), spatial resolution, anatomical delineation, and anatomical and functional contrast. When combined with the appropriate imaging methods, these gains can be transformative in basic and translational neuroscience projects. However, access to such advanced capabilities by neuroscience researchers is virtually impossible outside the context of a collaborative and multidisciplinary relationship, especially (but not only) when instrumentation at the cutting-edge of the field, such as those operating at high (HF) and ultrahigh fields (UHF), and advanced, asof- yet commercially unavailable imaging methods are employed. The aim of this core is to provide the necessary support and infrastructure that will allow a large community of NINDS funded investigators to utilize advanced imaging methodologies and instrumentation in CMRR where there exists a large parallel effort (funded by other sources) on instrumentation and methodology development.

1.高场和超高场图像采集与工程 PI：Pierre-Francois货车de Moortlele，博士 核心目标 该核心的长期目标是提供增强、拓宽和加速大型阵列的手段 雄心勃勃的神经科学研究项目，越来越多地利用高（3和4 T）和低（7 T） 和以上）场MR成像仪器和新颖的图像采集和重建技术， 研究大脑结构和功能。多项研究已经充分证明，MRI在更高的 磁场可以在信噪比（SNR），空间分辨率， 解剖学描绘以及解剖学和功能对比。当与适当的成像相结合时 方法，这些收益可以在基础和转化神经科学项目的变革。然而，神经科学研究人员在合作和多学科关系的背景下几乎不可能获得这种先进的能力，特别是（但不仅是）当该领域的尖端仪器，例如在高（HF）和超高频（UHF）下操作的仪器，以及先进的，迄今为止尚未商业化的成像方法被采用时。该核心的目的是提供必要的支持和基础设施，使大量NINDS资助的研究人员能够在CMRR中利用先进的成像方法和仪器，其中存在大量并行的仪器和方法开发工作（由其他来源资助）。