Enhancing Participation of Underrepresented Groups in Biomarker Studies

该项目将需要与威斯康星州部落和民族/种族少数群体的代表合作，进行一项旨在确定和加强生物标志物研究参与的研究。生物标志物研究依赖于收集体液，如血液或脑脊液，组织，功能或结构成像。特别重要的是，要让部落、移民和少数民族人口参与这些研究，因为这些群体在慢性病和残疾方面承受着不成比例的负担。未能让这些群体参与生物标志物研究，实际上是由于未能确定生物标志物的作用， 风险差异的原因以及环境、社会经济和行为变量对健康结果的中介/调节作用。我们将使用基于社区的参与性研究（CBPR）方法来识别和解决生物标志物研究参与的障碍。使用基于卫生服务利用框架的混合方法，社区学术研究团队将研究参与阿尔茨海默病，肺和心血管疾病和癌症生物标志物研究项目的障碍和促进因素。该框架基于计划行为/理性行为理论（TPB）和Andersen的健康行为模式（HBM），已被用于研究参与癌症临床试验的意愿。它关注影响行为意图（参与决策）的认知因素。这些团队的研究结果将有助于为文化定制的教育材料的开发提供信息，这些材料将被试用，以检查是否/如何可以测量参与生物标志物研究的意图。我们的活动旨在提高少数群体和医疗服务不足的个人在生物标志物研究中的知名度和参与度。

This project will entail partnering with representatives of Wisconsin tribal and ethnic/racial minority groups in a study designed to identify and enhance participation in biomarker research. Biomarkers research relies upon the collection of bodily fluids such as blood or cerebrospinal fluid, tissue, functional or structural imaging. It is particularly important to engage tribal, immigrant and minority populations in these studies since these groups bear a disproportionate burden of chronic disease and disability. The failure to engage such groups in biomarker research actually serves to increase health disparity 'gaps' by failing to identify the causes of risk differences and mediating/moderating effects of environmental, socioeconomic and behavioral variables on health outcomes. We will use a community based participatory research (CBPR) approach to identify and address the barriers to biomarker study participation. Using a mixed methods approach based on a health services utilization framework, community-academic research teams will examine barriers and facilitators to participation in biomarker research projects for Alzheimer's, pulmonary and cardiovascular disease and cancer. This framework, based on the Theory of Planned Behavior/Reasoned Action (TPB) and Andersen's health behavior mode (HBM), has been used to examine willingness to participate in cancer clinical trials. It focuses on the cognitive factors that effect behavioral intentions (the decision to participate). The findings of these teams will serve to inform the development of culturally tailored educational materials that will be piloted to examine whether/how intent to participate in biomarker research can be measured. Our activities in whole are designed to bring visibility to and increase participation of minority and medically underserved individuals in biomarker studies.