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Circadian Misalignment and Energy Metabolism

昼夜节律失调和能量代谢

基本信息

批准号：
8464698
负责人：
Kenneth P Wright
金额：
$ 17.68万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-01 至 2014-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8464698
关键词：
Address Adipose tissue Animal Model Animals Area Arousal Behavior Behavioral Biological Biomedical Research Brain region Calorimetry Cardiovascular Diseases Center for Translational Science Activities Circadian Rhythm Sleep Disorders Circadian Rhythms Classification Clinical Research DSM-V Data Development Diabetes Mellitus Disease Eating Eating Disorders Emergency Situation Endocrine Physiology Energy Metabolism Epidemic Event Exploratory/Developmental Grant Fatty acid glycerol esters Food Genes Goals Health Healthcare Hormones Hour Human Human Resources Hypothalamic structure Intake Jet Lag Syndrome Lead Leptin Light Liver Macronutrients Nutrition Metabolic Metabolic syndrome Modeling Mus Muscle Obesity Outcome Outcome Measure Overweight Pancreas Peripheral Phenotype Physical activity Physiological Physiology Research Research Project Grants Role Schedule Security Sleep Sleep Disorders System Testing Time Tissues Translating United States National Institutes of Health Weight Gain Work base circadian pacemaker design energy balance feeding field study follow-up frontier ghrelin increased appetite infancy mouse model mutant obesity risk operation oxidation primary outcome research study response secondary outcome shift work suprachiasmatic nucleus theories treatment strategy

项目摘要

DESCRIPTION (provided by applicant): The interplay of circadian timing and metabolic physiology represents a new frontier in biomedical research. Research on weight gain in humans has focused primarily on macronutrient intake and energy expenditure, the latter predominantly through physical activity, to understand and treat overweight and obesity. Emerging evidence from animal models indicates that circadian physiology impacts weight gain, including the observation of obesity in clock gene mutants and most recently the finding that food intake restricted to the habitual sleep time of mice leads to weight gain as compared to the same amount of food intake during the normal wake episode. We propose to determine if findings from these mouse models translate to humans. To do so, we have designed an exploratory Clinical and Translational Research Center (CTRC) study that uses whole room calorimetry to determine how restricting the majority of food intake to the biological night impacts energy metabolism in humans. Eating at night is common in work schedules with long work hours and with work operations during the nighttime hours (e.g., health care, emergency response, security personnel) and in circadian sleep disorders including, but not limited to, shift work and jet lag disorder. Night eating disorders are also newly recognized conditions that may contribute to obesity. The project addresses several themes outlined in NIH PA NUMBER: 09-124 "Exploratory/Developmental Clinical Research Grants in Obesity" by testing the following specific hypothesis: i) circadian misalignment will lead to reduced fat oxidation-a physiological state that could contribute to weight gain. This research effort is responsive to PA-09-124 as it will assess how a behavioral phenotype of eating at night increases risk for obesity and will contribute to identification of this behavior as a modifiable determinant of overweight and obesity.

描述（由申请人提供）：昼夜节律和代谢生理学的相互作用代表了生物医学研究的新前沿。关于人类体重增加的研究主要集中在常量营养素摄入和能量消耗上，后者主要通过身体活动来理解和治疗超重和肥胖。来自动物模型的新证据表明，昼夜生理会影响体重增加，包括对时钟基因突变中肥胖的观察，以及最近的发现，与正常清醒期间摄入相同数量的食物相比，限制小鼠习惯性睡眠时间的食物摄入会导致体重增加。我们打算确定这些小鼠模型的发现是否适用于人类。为此，我们设计了一项探索性临床和转化研究中心（CTRC）研究，该研究使用全室量热法来确定将大部分食物摄入限制在生物夜间如何影响人类的能量代谢。在工作时间长、夜间作业（如保健、应急、保安人员）和昼夜节律睡眠障碍（包括但不限于倒班）的工作安排中，夜间进食很常见

项目成果

期刊论文数量（5）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Early Morning Food Intake as a Risk Factor for Metabolic Dysregulation.

清晨食物摄入是代谢失调的危险因素。

DOI：
10.3390/nu12030756
发表时间：
2020
期刊：
Nutrients
影响因子：
5.9
作者：
Stothard,EllenR;Ritchie,HannahK;Birks,BrianR;Eckel,RobertH;Higgins,Janine;Melanson,EdwardL;WrightJr,KennethP;McHill,AndrewW
通讯作者：
McHill,AndrewW

Entrainment of the Human Circadian Clock to the Light-Dark Cycle and its Impact on Patients in the ICU and Nursing Home Settings.

人类昼夜节律时钟对光暗周期的影响及其对 ICU 和疗养院患者的影响。