Biomarkers for Peripheral Circadian Clocks in Humans

人类外周生物钟的生物标志物

基本信息

批准号：
10687428
负责人：
Kenneth P Wright
金额：
$ 77.95万
依托单位：
UNIVERSITY OF COLORADO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-20 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10687428
关键词：
Address Adipose tissue Behavior Behavioral Biological Markers Body Temperature C-reactive protein Cells Circadian Rhythms Circadian desynchrony Clinical Trials Cues Data Development Disease Eating Endothelial Cells Endothelium Food Future Gene Expression Glucocorticoids Glucose Goals Health Hormones Human Hydrocortisone Hypothalamic structure Immune Isomerism Knowledge Lead Leptin Ligands Light Liver Melatonin Metabolic Methodology Outcome Parathyroid gland Peptide YY Periodicity Peripheral Phase Physical activity Physiological Physiological Processes Plasma Proteins Plasminogen Activator Inhibitor 1 Precision Medicine Initiative Process Proteins Proteome Proteomics Protocols documentation Publishing Randomized Regulation Research Sampling Sleep Disorders Small Intestines Stomach Strategic Planning Structure Sympathetic Nervous System Testing Theoretical model Time Tissues United States National Institutes of Health analytical tool base biomarker development bone chemokine circadian circadian pacemaker fundamental research ghrelin improved in vivo men novel novel marker response suprachiasmatic nucleus treatment strategy

项目摘要

PROJECT SUMMARY/ABSTRACT Circadian clocks are present in most tissues of the body with importance for optimal physiological function and behavior. Misalignment or disruption of peripheral circadian clocks contribute to disease and thus represent promising novel treatment targets to improve health. The overall goal of this proposal is to improve our understanding of peripheral circadian clocks in humans. We will conduct a seven-weeklong randomized, crossover, mechanistic clinical trial to 1) test zeitgebers (time cues) for already identified markers of peripheral clocks, and 2) identify novel biomarkers for peripheral clocks and explore zeitgebers for those clocks in humans. Preliminary data from our human circadian basic and clinical trial research set the stage for this proposal. This mechanistic clinical trial effort is a first step to inform future development of novel circadian based treatments for aligning peripheral clocks and for developing novel circadian biomarkers that will advance our scientific understanding of circadian rhythms. Our overall goal and aims support the NIH Precision Medicine Initiative and the NIH Sleep Disorders Research Strategic Plan.

项目摘要/摘要昼夜节律时钟都存在于人体的大多数组织中，对最佳生理功能和行为。外周昼夜钟的错位或破坏会导致疾病，因此代表有前途的新型治疗目标可以改善健康。该提议的总体目标是改善我们的了解人类的外围昼夜节律。我们将进行七个周的随机，跨界，机械临床试验至1）已确定的周围标记的测试Zeitgebers（时间提示）时钟和2）确定外围钟的新型生物标志物，并为人类中的那些时钟探索Zeitgebers。我们人类昼夜节律基础和临床试验研究的初步数据为该提案奠定了基础。这机械临床试验工作是为未来开发的新型基于昼夜节律治疗的第一步对齐外围钟和开发新颖的昼夜节律生物标志物，这些生物标志物将推进我们的科学了解昼夜节律。我们的总体目标和目标支持NIH Precision Medicine Initiative和 NIH睡眠障碍研究战略计划。