Biomarkers for Peripheral Circadian Clocks in Humans
Biomarkers for Peripheral Circadian Clocks in Humans
批准号:
10687428
负责人:
Kenneth P Wright
金额:
$77.95万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2022
资助国家:
美国
项目状态:
已结题
起止时间:
2022-09-20 至 2024-08-31
关键词:
AddressAdipose tissueBehaviorBehavioralBiological MarkersBody TemperatureC-reactive proteinCellsCircadian RhythmsCircadian desynchronyClinical TrialsCuesDataDevelopmentDiseaseEatingEndothelial CellsEndotheliumFoodFutureGene ExpressionGlucocorticoidsGlucoseGoalsHealthHormonesHumanHydrocortisoneHypothalamic structureImmuneIsomerismKnowledgeLeadLeptinLigandsLightLiverMelatoninMetabolicMethodologyOutcomeParathyroid glandPeptide YYPeriodicityPeripheralPhasePhysical activityPhysiologicalPhysiological ProcessesPlasma ProteinsPlasminogen Activator Inhibitor 1Precision Medicine InitiativeProcessProteinsProteomeProteomicsProtocols documentationPublishingRandomizedRegulationResearchSamplingSleep DisordersSmall IntestinesStomachStrategic PlanningStructureSympathetic Nervous SystemTestingTheoretical modelTimeTissuesUnited States National Institutes of Healthanalytical toolbasebiomarker developmentbonechemokinecircadiancircadian pacemakerfundamental researchghrelinimprovedin vivomennovelnovel markerresponsesuprachiasmatic nucleustreatment strategy
中文摘要
项目总结/摘要
昼夜节律钟存在于身体的大多数组织中,对于最佳生理功能具有重要性,
行为外周生物钟的失调或破坏会导致疾病,因此代表
有望成为改善健康的新治疗靶点。该提案的总体目标是改善我们的
对人类外周生物钟的理解。我们将进行为期七周的随机,
交叉,机械临床试验,以1)测试已经确定的外周血淋巴细胞标志物的时间标记(时间线索)
生物钟,以及2)识别外周生物钟的新生物标志物,并探索人类中这些生物钟的时间表。
我们的人类昼夜节律基础和临床试验研究的初步数据为这一提议奠定了基础。这
机械临床试验工作是告知未来开发基于昼夜节律的新治疗方法的第一步。
调整外周生物钟,开发新的昼夜节律生物标志物,
对昼夜节律的理解。我们的总体目标和宗旨支持NIH精准医学计划,
NIH睡眠障碍研究战略计划
英文摘要
PROJECT SUMMARY/ABSTRACT
Circadian clocks are present in most tissues of the body with importance for optimal physiological function and
behavior. Misalignment or disruption of peripheral circadian clocks contribute to disease and thus represent
promising novel treatment targets to improve health. The overall goal of this proposal is to improve our
understanding of peripheral circadian clocks in humans. We will conduct a seven-weeklong randomized,
crossover, mechanistic clinical trial to 1) test zeitgebers (time cues) for already identified markers of peripheral
clocks, and 2) identify novel biomarkers for peripheral clocks and explore zeitgebers for those clocks in humans.
Preliminary data from our human circadian basic and clinical trial research set the stage for this proposal. This
mechanistic clinical trial effort is a first step to inform future development of novel circadian based treatments for
aligning peripheral clocks and for developing novel circadian biomarkers that will advance our scientific
understanding of circadian rhythms. Our overall goal and aims support the NIH Precision Medicine Initiative and
the NIH Sleep Disorders Research Strategic Plan.
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会议论文
Biomarkers for Peripheral Circadian Clocks in Humans
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批准号:10660517
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项目类别:
-
资助金额:$69.44万
-
财政年份:2023
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负责人:Kenneth P Wright
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依托单位:
Multi-Institutional Summer Undergraduate Research Program to Promote Diversity and Excellence in Sleep and Circadian Research Careers
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批准号:10594083
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项目类别:
-
资助金额:$13.46万
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财政年份:2023
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负责人:Kenneth P Wright
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依托单位:
Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder
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批准号:10660495
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项目类别:
-
资助金额:$69.84万
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财政年份:2023
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负责人:Kenneth P Wright
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依托单位:
Transdisciplinary Training in Sleep and Circadian Rhythms
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批准号:10403613
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项目类别:
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资助金额:$25.34万
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财政年份:2020
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负责人:Kenneth P Wright
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依托单位:
Transdisciplinary Training in Sleep and Circadian Rhythms
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批准号:10576970
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项目类别:
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资助金额:$25.96万
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财政年份:2020
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负责人:Kenneth P Wright
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依托单位:
Association of habitual sleep duration with plasma metabolomics
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批准号:10004739
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项目类别:
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资助金额:$12.51万
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财政年份:2019
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负责人:Kenneth P Wright
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依托单位:
Circadian Misalignment and Energy Metabolism
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批准号:8464698
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项目类别:
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资助金额:$17.68万
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财政年份:2012
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负责人:Kenneth P Wright
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依托单位:
Circadian Misalignment and Energy Metabolism
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批准号:8307207
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项目类别:
-
资助金额:$22.8万
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财政年份:2012
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负责人:Kenneth P Wright
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依托单位:
Metabolic and Cognitive Consequences of Sleep Loss
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批准号:8310252
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项目类别:
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资助金额:$53.33万
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财政年份:2011
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负责人:Kenneth P Wright
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依托单位:
Metabolic and Cognitive Consequences of Sleep Loss
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批准号:8528706
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项目类别:
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资助金额:$50.77万
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财政年份:2011
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负责人:Kenneth P Wright
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依托单位:
Metabolic and Cognitive Consequences of Sleep Loss
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批准号:8916942
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项目类别:
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资助金额:$20.43万
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财政年份:2011
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负责人:Kenneth P Wright
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依托单位:
Metabolic and Cognitive Consequences of Sleep Loss
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批准号:8162156
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项目类别:
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资助金额:$55.74万
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财政年份:2011
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负责人:Kenneth P Wright
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依托单位:
Metabolic and Cognitive Consequences of Sleep Loss
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批准号:8710326
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项目类别:
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资助金额:$52.26万
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财政年份:2011
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负责人:Kenneth P Wright
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依托单位:
Health and Safety Consequences of Sleep Loss
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批准号:7895703
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项目类别:
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资助金额:$47.63万
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财政年份:2009
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负责人:Kenneth P Wright
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依托单位:
Health and Safety Consequences of Sleep Loss
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批准号:7579576
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项目类别:
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资助金额:$48.4万
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财政年份:2009
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负责人:Kenneth P Wright
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依托单位:
THE METABOLIC COST OF EXTENDED WAKEFULNESS
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批准号:7719517
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项目类别:
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资助金额:$0.19万
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财政年份:2008
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负责人:Kenneth P Wright
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依托单位:
THE METABOLIC COST OF EXTENDED WAKEFULNESS
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批准号:7604467
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项目类别:
-
资助金额:$1.62万
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财政年份:2007
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负责人:Kenneth P Wright
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依托单位:
Circadian Integration of Photic and Non-photic Stimuli
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批准号:7388890
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项目类别:
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资助金额:$28.33万
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财政年份:2006
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负责人:Kenneth P Wright
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依托单位:
Circadian Integration of Photic and Non-photic Stimuli
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批准号:7629151
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项目类别:
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资助金额:$28.32万
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财政年份:2006
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负责人:Kenneth P Wright
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依托单位:
Circadian Integration of Photic and Non-photic Stimuli
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批准号:7098555
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项目类别:
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资助金额:$29.22万
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财政年份:2006
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负责人:Kenneth P Wright
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依托单位:
海外基金