Biomarkers for Peripheral Circadian Clocks in Humans

项目概要/摘要 昼夜节律钟存在于身体的大多数组织中，对于最佳生理功能具有重要性， 行为外周生物钟的失调或破坏会导致疾病，因此代表 有望成为改善健康的新治疗靶点。该提案的总体目标是改善我们的 对人类外周生理节律的理解。我们将进行为期七周的 随机、交叉、机械临床试验，以1）测试外周昼夜节律的时间标志（时间线索） 节律，和2）识别外周节律的新生物标志物，并探索这些节律的时间表。 人类我们的人类昼夜节律基础和临床试验研究的初步数据为此奠定了基础 提议这种机械临床试验的努力是第一步，通知未来发展的新昼夜节律 用于调整外周生物钟和开发新的昼夜节律生物标志物的基础治疗， 推进我们对昼夜节律的科学理解。我们的总体目标和目的支持NIH 精准医学倡议和NIH睡眠研究战略计划。

PROJECT SUMMARY/ABSTRACT Circadian clocks are present in most tissues of the body with importance for optimal physiological function and behavior. Misalignment or disruption of peripheral circadian clocks contribute to disease and thus represent promising novel treatment targets to improve health. The overall goal of this proposal is to improve our understanding of peripheral circadian rhythms in humans. We will conduct a seven-weeklong randomized, crossover, mechanistic clinical trial to 1) test zeitgebers (time cues) for peripheral circadian rhythms, and 2) identify novel biomarkers for peripheral rhythms and explore zeitgebers for those rhythm in humans. Preliminary data from our human circadian basic and clinical trial research set the stage for this proposal. This mechanistic clinical trial effort is a first step to inform future development of novel circadian based treatments for aligning peripheral clocks and for developing novel circadian biomarkers that will advance our scientific understanding of circadian rhythms. Our overall goal and aims support the NIH Precision Medicine Initiative and the NIH Sleep Research Strategic Plan.