Optical coherence tomography equipped wavefront system for studying accommodation

描述（由申请人提供）：用于研究调节的光学相干断层扫描装备波前系统在人眼中，在一定观看距离内的清晰视觉是通过称为调节的生物过程实现的，通过该过程，由于睫状肌收缩引起的晶状体形状的变形而使屈光能力发生变化。对视力调节的研究对公共卫生很有意义，因为与年龄相关的视力调节的丧失会导致几乎每只眼睛都有老花，同时，视力调节不准确会增加小学生患近视的风险。但是，由于技术限制，睫状肌和晶状体的几何变化都没有在体内精确测量。目前还没有技术可以同时评估所有可调节组件的行为并测试彼此之间的相互作用。到目前为止，我们对每个组成部分的贡献知之甚少，无论是从数量上讲，还是从其与其他组成部分的相互作用上讲，都是对正常、异常甚至丧失适应性的影响。因此，对控制老花眼和近视的发展进行有效的干预，或计划老花眼手术，如调节人工晶状体和晶状体充填，仍然很难预测成功。本项目的总体目标是开发一种新的光学系统，用于同时测量睫状肌收缩、晶状体变形和人眼在体内调节过程中的光学性能。新系统将采用波前像差法、前房光学相干层析成像（AC-OCT）和前巩膜光学相干层析成像（AS-OCT）三种技术。使用波前技术将使我们能够估计折射率和高阶像差的可调节变化。AC-OCT将提供一种独特的仪器来成像整个前段和整个晶状体。AS-OCT将使我们能够以前所未有的准确性评估睫状肌收缩。使用新系统的优势包括：(1)更准确地测量每个关键组成部分的适应性变化；(2)同时对其绩效进行评估。此外，本研究旨在得出不同年龄成人的光学性能与睫状肌收缩和/或晶状体形状变形之间的定量关系。我们的目标的成功实现将使我们成为第一个同时准确测量体内调节系统的人。这种方法将有助于我们更好地了解各调节成分的功能作用，从而找到有效的干预措施来控制老花眼和近视的发展。它还将在评估当前老花眼治疗方法的方法上取得重大突破。本项目开发的技术可以通过出版物进行分享，有可能产生重大的实际应用，提高生活质量，从而对公众健康产生重大的积极影响。

DESCRIPTION (provided by applicant): Optical coherence tomography equipped wavefront system for studying accommodation In the human eye a clear vision over a range of viewing distances is achieved through a biological process called accommodation, by which refractive power is varied due to a deformation of the shape of the crystalline lens, brought about by a contraction of the ciliary muscle. The study of accommodation is interesting to public health because age-related loss of the accommodation leads to presbyopia in almost every eye and meanwhile inaccurate accommodation increases the risk to develop myopia in schoolchildren. But, due to the technical limitations, geometric changes in both the ciliary muscle and the lens have not been accurately measured in vivo. No technique is currently available to simultaneously assess the behavior of all accommodative components and to test interactions between each others. So far, we know very little about the contribution from each component, quantitatively by itself or by its interaction with the others, to a normal, abnormal or even loss of accommodation. As such, it is still difficult to make effective intervention to control presbyopia and myopia development or to plan presbyopia surgeries, such as accommodative IOL and lens refilling, with a predictable success. The overall goal of this proposed project is to develop a novel optical system to be used for simultaneously measuring ciliary muscle contraction, lens deformation and optical performance of the human eye during accommodation in vivo. Three techniques including the wavefront aberrometry, the anterior chamber optical coherence tomography (AC-OCT) and the anterior sclera optical coherence tomography (AS-OCT) will be employed and integrated into the new system. Use of the wavefront technique will allow us to estimate accommodative changes in refractive power and higher order aberrations. The AC-OCT will provide a unique instrumentation to image the entire anterior segment and the whole lens. The AS-OCT will allow us to assess ciliary muscle contraction with unprecedented accuracy. Promised advantages by using the new system include (1) more accurate measurement of accommodative change in each of the key components; and (2) simultaneous assessment of their performances together. In addition, this proposal is aimed to derive quantitative relationships between optical performance and the ciliary muscle contraction and/or the lens shape deformation for adults at different ages. Successful accomplishment of our goals will make us the first to simultaneously and accurately measure accommodation system in vivo. This method will help us to better understand the functional role of each accommodative component, and thus to find effective interventions to control the development of presbyopia and myopia. It will also present a substantial breakthrough in the methodology to evaluate current presbyopia treatments. The technology developed in this project can be shared through publications and holds the potential to produce significant tangible applications that enhance quality of life and therefore have a significant positive impact on public health.