Optical coherence tomography equipped wavefront system for studying accommodation

描述（由申请人提供）：用于研究调节的配备有光学相干断层扫描的波前系统在人眼中，通过称为调节的生物过程来实现在观看距离范围内的清晰视觉，通过调节，由于睫状肌的收缩引起的晶状体透镜的形状变形，折射力发生变化。调节的研究对公共卫生很有意义，因为与年龄相关的调节丧失导致几乎每只眼睛的老花眼，同时不准确的调节增加了学龄儿童患近视的风险。但是，由于技术的限制，在睫状肌和透镜的几何变化还没有被准确地测量在体内。目前还没有技术可以同时评估所有分解组分的行为并测试彼此之间的相互作用。到目前为止，我们对每一个组成部分的贡献知之甚少，无论是定量的还是与其他组成部分的相互作用，对调节的正常、异常甚至丧失都是如此。因此，仍然难以进行有效的干预来控制老花眼和近视眼的发展或计划老花眼手术，例如矫正性IOL和透镜再填充，并取得可预测的成功。本项目的总体目标是开发一种新型的光学系统，用于在活体调节过程中同时测量人眼的睫状肌收缩、透镜变形和光学性能。将波前像差测量、前房光学相干断层扫描（AC-OCT）和前巩膜光学相干断层扫描（AS-OCT）三种技术整合到新系统中。波前技术的使用将使我们能够估计屈光力和高阶像差的重复变化。AC-OCT将提供一种独特的仪器，用于对整个前段和整个透镜进行成像。AS-OCT将使我们能够以前所未有的准确度评估睫状肌收缩。使用新系统的预期优势包括：（1）更准确地测量每个关键组件的替代变化;（2）同时评估它们的性能。此外，本提案旨在导出不同年龄的成人的光学性能与睫状肌收缩和/或透镜形状变形之间的定量关系。我们目标的成功实现将使我们成为第一个同时准确测量体内调节系统的人。这种方法将有助于我们更好地了解每个屈光成分的功能作用，从而找到有效的干预措施来控制老花眼和近视眼的发展。它还将在评估当前老视治疗的方法学方面取得重大突破。该项目开发的技术可以通过出版物分享，并有可能产生重要的实际应用，提高生活质量，从而对公共卫生产生重大的积极影响。

DESCRIPTION (provided by applicant): Optical coherence tomography equipped wavefront system for studying accommodation In the human eye a clear vision over a range of viewing distances is achieved through a biological process called accommodation, by which refractive power is varied due to a deformation of the shape of the crystalline lens, brought about by a contraction of the ciliary muscle. The study of accommodation is interesting to public health because age-related loss of the accommodation leads to presbyopia in almost every eye and meanwhile inaccurate accommodation increases the risk to develop myopia in schoolchildren. But, due to the technical limitations, geometric changes in both the ciliary muscle and the lens have not been accurately measured in vivo. No technique is currently available to simultaneously assess the behavior of all accommodative components and to test interactions between each others. So far, we know very little about the contribution from each component, quantitatively by itself or by its interaction with the others, to a normal, abnormal or even loss of accommodation. As such, it is still difficult to make effective intervention to control presbyopia and myopia development or to plan presbyopia surgeries, such as accommodative IOL and lens refilling, with a predictable success. The overall goal of this proposed project is to develop a novel optical system to be used for simultaneously measuring ciliary muscle contraction, lens deformation and optical performance of the human eye during accommodation in vivo. Three techniques including the wavefront aberrometry, the anterior chamber optical coherence tomography (AC-OCT) and the anterior sclera optical coherence tomography (AS-OCT) will be employed and integrated into the new system. Use of the wavefront technique will allow us to estimate accommodative changes in refractive power and higher order aberrations. The AC-OCT will provide a unique instrumentation to image the entire anterior segment and the whole lens. The AS-OCT will allow us to assess ciliary muscle contraction with unprecedented accuracy. Promised advantages by using the new system include (1) more accurate measurement of accommodative change in each of the key components; and (2) simultaneous assessment of their performances together. In addition, this proposal is aimed to derive quantitative relationships between optical performance and the ciliary muscle contraction and/or the lens shape deformation for adults at different ages. Successful accomplishment of our goals will make us the first to simultaneously and accurately measure accommodation system in vivo. This method will help us to better understand the functional role of each accommodative component, and thus to find effective interventions to control the development of presbyopia and myopia. It will also present a substantial breakthrough in the methodology to evaluate current presbyopia treatments. The technology developed in this project can be shared through publications and holds the potential to produce significant tangible applications that enhance quality of life and therefore have a significant positive impact on public health.