Training Program in Quantitative Ocular Genomics

定量眼部基因组学培训计划

• 批准号: 8463545
• 负责人: Milam A Brantley
• 金额: $ 13.99万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8463545
• 关键词: Genomics; Training Programs

Human genetics has emerged over the past 50 years as a dominant force in biology and medicine. This critical position stems not only from its central importance in explaining the most basic biological processes, but also from its growing repertoire of critical technologies and methods that can elucidate molecular, cellular, organismal, and population biology. However, the application of these technologies and methods to different diseases and phenotypes has varied greatly. Despite the medical, social, and cultural importance of eyesight, genetic studies of ocular phenotypes have lagged behind other disease entities. This is due in part to the lack of cross-disciplinary training opportunities. The primary goal of this Training Program in Quantitative Ocular Genomics is to fill this gap by training a new generation of ocular researchers who have specific expertise in genomic analysis. The proposed Training Program in Quantitative Ocular Genomics requests two pre-doctoral and four post-doctoral training slots. It builds upon the substantial increase in resources, faculty, facilities, and expertise in both ophthalmology (through the Vanderbilt Eye Institute) and human genetics (through the Center for Human Genetics Research) at Vanderbilt. For pre-doctoral training it also builds upon Vanderbilt's existing pre-doctoral Interdisciplinary Graduate Program (IGP) and its excellent and large pool of student applicants. Our goal is to train future investigators to characterize genetic variation and understand its phenotypic implications on ocular phenotypes in humans. Vanderbilt has particular strengths in statistical genetics, computational genomics, genetic epidemiology, bioinformatics, and clinical and basic ophthalmological research. All pre-doctoral trainees will undergo a rigorous didactic program and intensive research training. Post-doctoral trainees will be integrated into our extensive and rich research environment. We have enhanced this training program with regular seminars, journal clubs, an informal works-in-progress seminar, and an annual retreat. To ensure a balanced and complete training experience, each trainee will be co-mentored by a preceptor with extensive experience in genomics and another in ocular function.

在过去的50年中，人类遗传学一直是生物学和医学领域的主要力量。 这种关键位置不仅源于其在解释最基本的生物学方面的重要性 流程，以及从越来越多的关键技术和方法的曲目来阐明 分子，细胞，生物和种群生物学。但是，这些应用 不同疾病和表型的技术和方法变化很大。尽管有 视力的医学，社会和文化重要性，眼科表型的遗传研究滞后 其他疾病实体背后。这部分是由于缺乏跨学科培训机会。 该定量眼基因组学培训计划的主要目标是通过培训来填补这一空白 新一代的眼科研究人员，在基因组分析方面具有特定的专业知识。 定量眼基因组学的拟议培训计划要求两个前博士和四个 博士后培训插槽。它建立在资源，教职员工，设施和 通过范德比尔特眼科研究所和人类遗传学（通过 人类遗传学研究中心）在范德比尔特（Vanderbilt）。对于博士前培训，它也基于 范德比尔特（Vanderbilt）现有的博学前跨学科研究生课程（IGP）及其出色而大型 学生申请人库。我们的目标是培训未来的调查人员以表征遗传变异 并了解其对人类眼部表型的表型意义。范德比尔特有特殊之处 统计遗传学，计算基因组学，遗传流行病学，生物信息学和 临床和基本眼科研究。所有博士前学员将经历严格的教学 计划和强化研究培训。博士后学员将融入我们的广泛 和丰富的研究环境。我们通过常规研讨会加强了该培训计划， 期刊俱乐部，非正式的正在进行的研讨会和年度务虚会。确保平衡 和完整的培训经验，每个受训者将由一个官员共同授予 具有基因组学的经验，另一个在眼功能方面。