Stereoselective Allyl Coupling Reactions

描述(由申请人提供)：催化不对称构筑C-C键的新方法具有重要意义。在正确的背景下，这些方法可以被证明是全合成的关键反应，它们可以为有用的治疗剂提供新的和更有效的途径。沿着这些思路，单一对映体手性化合物作为新材料和药物相关疗法是至关重要的。事实上，最近的一篇综述文章证实，截至2003年，上市的新药中有整整50%是单一对映体手性实体。此外，据估计，任何时候都有500-1000种单一对映体化合物在全球药物流水线中。显然，我们制备这种手性治疗剂的能力可以通过引入催化的对映选择性化学转化而大大增强，这些转化导致了从根本上新的合成断开。这项研究将把我们在催化共轭烯丙基化反应方面的成果扩展到更广泛的对映选择性交叉偶联反应。

DESCRIPTION (provided by applicant): New methods for catalytic enantioselective construction of C-C bonds are fundamentally significant. In the right context, such methods can prove to be lynchpin reactions for total synthesis and they can offer new and more efficient routes to useful therapeutic agents. Along these lines, single enantiomer chiral compounds are vitally important as new materials and as medicinally relevant therapies. Indeed, one recent review article established that as of 2003, fully 50% of new drugs brought to market are single enantiomer chiral entities. Further, it was estimated that 500-1000 single enantiomer compounds are in the global drug pipeline at any one time. Clearly, our ability to prepare such chiral therapeutic agents can be enhanced substantially by the introduction of catalytic enantioselective chemical transformations that result in fundamentally new synthetic disconnections. The proposed research will extend our fruitful studies on catalytic conjugate allylation reactions to a much broader range of enantioselective cross-coupling reactions.