Stereoselective Allyl Coupling Reactions

描述（由申请人提供）：催化对映选择性构建C-C键的新方法具有根本意义。在适当的情况下，这些方法可以被证明是全合成的关键反应，它们可以为有用的治疗剂提供新的和更有效的途径。沿着这些思路，单对映体手性化合物作为新材料和医学相关疗法至关重要。事实上，最近的一篇评论文章指出，截至2003年，上市的新药中有50%是单对映体手性实体。此外，据估计，在任何时候，全球药物管道中都有500-1000种单一对映体化合物。显然，我们制备这种手性治疗剂的能力可以通过引入催化对映选择性化学转化而大大增强，从而产生新的合成断开。本研究将把我们在催化共轭烯丙化反应方面卓有成效的研究扩展到更广泛的对映选择性交叉偶联反应。

DESCRIPTION (provided by applicant): New methods for catalytic enantioselective construction of C-C bonds are fundamentally significant. In the right context, such methods can prove to be lynchpin reactions for total synthesis and they can offer new and more efficient routes to useful therapeutic agents. Along these lines, single enantiomer chiral compounds are vitally important as new materials and as medicinally relevant therapies. Indeed, one recent review article established that as of 2003, fully 50% of new drugs brought to market are single enantiomer chiral entities. Further, it was estimated that 500-1000 single enantiomer compounds are in the global drug pipeline at any one time. Clearly, our ability to prepare such chiral therapeutic agents can be enhanced substantially by the introduction of catalytic enantioselective chemical transformations that result in fundamentally new synthetic disconnections. The proposed research will extend our fruitful studies on catalytic conjugate allylation reactions to a much broader range of enantioselective cross-coupling reactions.