Catalytic Enantioselective Diboration Reactions

描述(申请人提供)：拟议的研究将继续我们在开发烯烃二硼反应方面的努力。这些转化允许廉价的烯烃和二烯底物选择性地转化为单一对映体手性化合物。值得注意的是，这些新工艺产生的反应产物的类型很难用其他技术制造。在这项工作中，我们将研究对映选择性二硼反应的机理，以便开发出更有效的催化剂。我们还将介绍新的手性单齿配体结构，这些结构对双硼反应和其他过程也是有用的。最后，我们将探讨这些方法在解决不对称合成中存在的问题方面的应用。 公共卫生相关性：单一对映体手性化合物是现代人类治疗中的重要结构。利手：伴随着各种类型的结构，它们能够：适应：进入生理药物靶点。这项拟议的研究旨在开发新的工艺，允许经济地构建这些类型的化合物。

DESCRIPTION (provided by applicant): The proposed research will continue our efforts in the development of alkene diboration reactions. These transformations allow the selective conversion of inexpensive alkene and diene substrates into single enantiomer chiral compounds. Notably, the types of reaction products that arise from these new processes are difficult to make with other technologies. In the proposed work, we will study the mechanism of enantioselective diboration reactions so that we can develop more efficient catalysts. We will also introduce new chiral monodentate ligand structures that should be useful for the diboration reaction and other processes as well. Lastly, we will explore the utility of these processes to solve extant problems in asymmetric synthesis. PUBLIC HEALTH RELEVANCE: Single enantiomer chiral compounds are important structures in modern human therapeutics. The handedness: that accompanies types of structures enables them to :fit: into physiological drug targets. The proposed research aims to develop new processes that allow for the economical construction of these types of chemical compounds.