UNC-CH NADIA Administrative Core

描述（由申请人提供）：本申请的目的是为“成年期青少年饮酒的神经生物学”（NADIA）倡议建立一个联盟。NADIA将在一个多学科研究项目中协调不同的基础神经科学家小组，以明确青少年酒精暴露对成年人的持续影响，并开始探索神经生物学机制。该联盟的首要假设是，人类未成年饮酒模型将影响大脑成熟，导致与行为变化相关的成年大脑功能和结构的持续变化。该NADIA将使用青少年间歇性乙醇（AIE）大鼠模型，模拟人类青少年未成年饮酒的情景。多个研究组成部分将整合分子，细胞，生理，内分泌，遗传神经解剖和行为研究，利用尖端和新的方法来调查人类未成年饮酒的潜在长期后果。大量的证据表明，在青春期，认知，影响和奖励驱动的行为剧目是独特的塑料和响应环境的影响。作为动机、情感和决策基础的大脑回路的成熟预计对乙醇破坏敏感，从而导致成人精神病理学的增加。该联盟将整合共享共同假设和重叠协议的研究人员。每一个都将有助于更好地理解青少年酒精暴露对大脑生理学，结构，化学，成熟和行为诱导的影响，动机，社会功能，决策认知评估，冲动，昼夜节律和饮酒行为的影响，使用AIE的后果。内容涵盖了广泛的相互关联的调查之间的神经回路额叶皮质，纹状体，海马，杏仁核和下丘脑核，以及下丘脑-肾上腺的相互作用跨性别的激素成熟，提供了一个广泛的全球调查的神经网络的发展，背后的复杂行为的成熟。科学核心将提供脑MRI-DTI（脑体积-结构），脑区域组织学-免疫组织化学的组件，并为未来的脑网络分析建立数据库。了解未成年人饮酒对成年人神经生物学的影响对于指导公共卫生举措非常重要。

DESCRIPTION (provided by applicant): The purpose of this application is to develop a Consortium for the initiative "Neurobiology of Adolescent Drinking in Adulthood" (NADIA). The NADIA will coordinate a diverse group of basic neuroscientists in a multidisciplinary research project to clearly define the persistent effects of adolescent alcohol exposure on adults, and to begin to explore the neurobiological mechanisms. The overarching hypothesis of this consortium is that models of human underage drinking will impact brain maturation resulting in persistent changes in adult brain function and structure that relate to changes in behavior. This NADIA will use adolescent intermittent ethanol (AIE) rat models that mimic episodic human adolescent underage drinking. Multiple research components will integrate molecular, cellular, physiological, endocrine, genetic neuroanatomical and behavioral studies utilizing cutting edge and novel approaches to investigate potential long term consequences of human underage drinking. An abundance of evidence suggests that during adolescence, cognition, affect, and reward driven behavioral repertoires are uniquely plastic and responsive to environmental influences. Maturation of brain circuitry that underlies motivation, affect and decision making are expected to be sensitive to ethanol disruption, resulting in increased adult psychopathology. This consortium will integrate investigators that share common hypotheses and overlapping protocols. Each will contribute to an improved understanding of the consequences of adolescent alcohol exposure on brain physiology, structure, chemistry, maturation and behavioral induces of affect, motivation, social functioning, decision-making cognitive assessments, impulsivity, circadian rhythms, and alcohol drinking behaviors using AIE. Components cover broad inter-related investigations of the neurocircuitry between frontal-cortical, striatal, hippocampal, extended amygdala and hypothalamic nuclei as well as hormonal maturation of hypothalamic-adrenal interactions across gender, providing a broad global investigation of the development of neural networks that underlie maturation of complex behaviors. The scientific core will provide components with brain MRI-DTI (brain volume - structure), brain regional histology-immunohistochemistry and establish a data repository for future brain network analysis. Understanding the impact of underage drinking on adult neurobiology is important to guide public health initiatives.