UNC-CH NADIA Administrative Core

描述（由申请人提供）：本申请的目的是为“成年期青少年饮酒的神经生物学”（NADIA）倡议建立一个联盟。NADIA将在一个多学科研究项目中协调不同的基础神经科学家小组，以清楚地确定青少年酒精暴露对成年人的持续影响，并开始探索神经生物学机制。该联盟的首要假设是，人类未成年人饮酒模型将影响大脑成熟，导致与行为变化相关的成人大脑功能和结构的持续变化。这个NADIA将使用青春期间歇乙醇（AIE）大鼠模型来模拟人类青春期未成年人饮酒的情景。多个研究组成部分将整合分子、细胞、生理、内分泌、遗传神经解剖学和行为研究，利用尖端和新颖的方法来调查人类未成年人饮酒的潜在长期后果。大量证据表明，在青春期，认知、情感和奖励驱动的行为是独特的可塑性和对环境影响的反应。作为动机、影响和决策基础的脑回路的成熟可能对乙醇的干扰很敏感，从而导致成人精神病理的增加。该联盟将整合具有共同假设和重叠协议的研究人员。每一项研究都将有助于更好地理解青少年酒精暴露对大脑生理、结构、化学、成熟和行为诱发的影响、动机、社会功能、决策认知评估、冲动、昼夜节律和使用AIE的饮酒行为的影响。组成部分涵盖了额叶-皮质、纹状体、海马、扩展杏仁核和下丘脑核之间的神经回路的广泛相互关联研究，以及下丘脑-肾上腺相互作用的激素成熟，提供了复杂行为成熟基础的神经网络发展的广泛全球研究。科学核心将提供脑MRI-DTI（脑体积-结构），脑区域组织学-免疫组织化学成分，并建立未来脑网络分析的数据存储库。了解未成年人饮酒对成人神经生物学的影响对指导公共卫生倡议非常重要。

DESCRIPTION (provided by applicant): The purpose of this application is to develop a Consortium for the initiative "Neurobiology of Adolescent Drinking in Adulthood" (NADIA). The NADIA will coordinate a diverse group of basic neuroscientists in a multidisciplinary research project to clearly define the persistent effects of adolescent alcohol exposure on adults, and to begin to explore the neurobiological mechanisms. The overarching hypothesis of this consortium is that models of human underage drinking will impact brain maturation resulting in persistent changes in adult brain function and structure that relate to changes in behavior. This NADIA will use adolescent intermittent ethanol (AIE) rat models that mimic episodic human adolescent underage drinking. Multiple research components will integrate molecular, cellular, physiological, endocrine, genetic neuroanatomical and behavioral studies utilizing cutting edge and novel approaches to investigate potential long term consequences of human underage drinking. An abundance of evidence suggests that during adolescence, cognition, affect, and reward driven behavioral repertoires are uniquely plastic and responsive to environmental influences. Maturation of brain circuitry that underlies motivation, affect and decision making are expected to be sensitive to ethanol disruption, resulting in increased adult psychopathology. This consortium will integrate investigators that share common hypotheses and overlapping protocols. Each will contribute to an improved understanding of the consequences of adolescent alcohol exposure on brain physiology, structure, chemistry, maturation and behavioral induces of affect, motivation, social functioning, decision-making cognitive assessments, impulsivity, circadian rhythms, and alcohol drinking behaviors using AIE. Components cover broad inter-related investigations of the neurocircuitry between frontal-cortical, striatal, hippocampal, extended amygdala and hypothalamic nuclei as well as hormonal maturation of hypothalamic-adrenal interactions across gender, providing a broad global investigation of the development of neural networks that underlie maturation of complex behaviors. The scientific core will provide components with brain MRI-DTI (brain volume - structure), brain regional histology-immunohistochemistry and establish a data repository for future brain network analysis. Understanding the impact of underage drinking on adult neurobiology is important to guide public health initiatives.