Southern HIV Alcohol Research Consortiium (SHARC) Admin and Research Support Core

描述（由申请人提供）：佛罗里达州是美国艾滋病新诊断率最高的州。艾滋病持续流行的特点是存在严重的种族差异和特殊人群，包括与男性发生性关系的妇女和男子。南部艾滋病毒酒精研究联盟（SHARC）于2011年作为CHAART成立，旨在解决佛罗里达州高风险酒精消费对艾滋病毒结果的影响。该联盟由三个独立资助的研究项目组成：纳曲酮在高风险饮酒的艾滋病毒感染妇女中的随机临床试验，一项正在进行的关注酒精对艾滋病毒神经认知和衰老影响的队列研究，以及一项酒精（和纳曲酮）对免疫衰老直接影响的免疫学研究。这些项目建立在一个成功的研究基础设施之上，该基础设施已经在佛罗里达州迈阿密招募了800多名艾滋病毒感染者，它们共享临床研究资源，并具有重叠的目标。然而，该联盟缺乏一个中央管理基础设施或机制来支持新的研究。根据RFA-AA-12-010提交的SHARC行政和研究支持核心，对于确保我们联盟项目之间的协调和沟通，形成新的多学科研究合作，并将我们的研究扩展到佛罗里达州的其他公共卫生环境至关重要。该核心的具体目标是(1)创建一个自我维持的跨学科研究联盟，解决佛罗里达州的艾滋病毒和危险饮酒问题（行政核心）；(2)扩大我们的研究和临床试验能力（研究支持）；(3)扩大多学科研究并指导新一代科学家（教育）。我们的研究人员带来了临床试验方法学、临床流行病学、免疫学、认知功能、卫生服务研究和运动方面的专业知识。总体而言，该核心将通过最大限度地提高总体研究生产力、提高开展临床试验的能力、加强合作、指导新研究人员以及将研究结果转化为临床实践和公共卫生环境来支持具有重大影响的研究，从而改善艾滋病毒感染者和高风险酒精合并症患者的健康结果。

DESCRIPTION (provided by applicant): The State of Florida has the highest rate of new HIV diagnoses in the US. Its ongoing epidemic is characterized by significant racial disparities and special populations including women and men who have sex with men. The Southern HIV Alcohol Research Consortium (SHARC) was created as a CHAART in 2011 to address the impact of high-risk alcohol consumption on HIV outcomes in Florida. The consortium consists of three independently-funded research projects: a randomized clinical trial of naltrexone in HIV-infected women with high-risk drinking, an ongoing cohort study focusing on the impact of alcohol on neurocognition and aging in HIV, and an immunology study of the direct impact of alcohol (and naltrexone) on immune senescence over time. The projects build upon a successful research infrastructure that has already recruited over 800 persons with HIV in Miami, Florida, share clinical research resources, and have overlapping aims. However, the consortium lacks a central administrative infrastructure or mechanism to support new research as a whole. The SHARC Administrative and Research Support Core, submitted in response to RFA-AA-12-010, is critically needed to ensure coordination and communication across our consortium projects, to form new, multidisciplinary research collaborations, and to extend our research into additional public health settings within Florida. The specific aims of this Core are (1) to create a self-sustaining, transdisciplinary research consortium addressing HIV and risky alcohol use in Florida (administrative core); (2) to expand our research and clinical trial capacities (research support); and (3) to expand multidisciplinary research and to mentor a new generation of scientists (education). Our investigators bring expertise in clinical trials methodology, clinical epidemiology, immunology, cognitive function, health services research, and exercise. Overall, the Core will support research that has significant impact by maximizing overall research productivity, increasing capacity to conduct clinical trials, enhancing collaborations, mentoring new researchers, and translating findings into clinical practice and public health settings that will improve health outcomes in persons with HIV and high-risk alcohol comorbidities.