Southern HIV Alcohol Research Consortiium (SHARC) Admin and Research Support Core

描述（由申请人提供）：佛罗里达州是美国艾滋病毒新诊断率最高的州。其持续流行的特点是严重的种族差异和特殊人群，包括与男子发生性关系的妇女和男子。南方艾滋病毒酒精研究联盟（SHARC）成立于2011年，旨在解决高风险酒精消费对佛罗里达艾滋病毒结果的影响。该联盟由三个独立资助的研究项目组成：纳洛酮在高危饮酒的艾滋病毒感染妇女中的随机临床试验，一项正在进行的队列研究，重点是酒精对艾滋病毒神经认知和衰老的影响，以及酒精（和纳洛酮）随时间对免疫衰老的直接影响的免疫学研究。这些项目建立在一个成功的研究基础设施上，该基础设施已经在佛罗里达的迈阿密招募了800多名艾滋病毒感染者，共享临床研究资源，目标重叠。然而，该联盟缺乏一个中央行政基础设施或机制来支持整个新研究。SHARC行政和研究支持核心，响应RFA-AA-12-010提交，是迫切需要的，以确保我们的财团项目之间的协调和沟通，形成新的，多学科的研究合作，并将我们的研究扩展到佛罗里达内的其他公共卫生环境。该核心的具体目标是：（1）在佛罗里达建立一个自我维持的跨学科研究联盟，解决艾滋病毒和危险酒精使用问题（行政核心）;（2）扩大我们的研究和临床试验能力（研究支持）;（3）扩大多学科研究，并指导新一代科学家（教育）。我们的研究人员带来了临床试验方法，临床流行病学，免疫学，认知功能，卫生服务研究和运动方面的专业知识。总体而言，核心将通过最大限度地提高整体研究生产力，提高进行临床试验的能力，加强合作，指导新研究人员，并将研究结果转化为临床实践和公共卫生环境，从而改善艾滋病毒和高危酒精合并症患者的健康结果，来支持具有重大影响的研究。

DESCRIPTION (provided by applicant): The State of Florida has the highest rate of new HIV diagnoses in the US. Its ongoing epidemic is characterized by significant racial disparities and special populations including women and men who have sex with men. The Southern HIV Alcohol Research Consortium (SHARC) was created as a CHAART in 2011 to address the impact of high-risk alcohol consumption on HIV outcomes in Florida. The consortium consists of three independently-funded research projects: a randomized clinical trial of naltrexone in HIV-infected women with high-risk drinking, an ongoing cohort study focusing on the impact of alcohol on neurocognition and aging in HIV, and an immunology study of the direct impact of alcohol (and naltrexone) on immune senescence over time. The projects build upon a successful research infrastructure that has already recruited over 800 persons with HIV in Miami, Florida, share clinical research resources, and have overlapping aims. However, the consortium lacks a central administrative infrastructure or mechanism to support new research as a whole. The SHARC Administrative and Research Support Core, submitted in response to RFA-AA-12-010, is critically needed to ensure coordination and communication across our consortium projects, to form new, multidisciplinary research collaborations, and to extend our research into additional public health settings within Florida. The specific aims of this Core are (1) to create a self-sustaining, transdisciplinary research consortium addressing HIV and risky alcohol use in Florida (administrative core); (2) to expand our research and clinical trial capacities (research support); and (3) to expand multidisciplinary research and to mentor a new generation of scientists (education). Our investigators bring expertise in clinical trials methodology, clinical epidemiology, immunology, cognitive function, health services research, and exercise. Overall, the Core will support research that has significant impact by maximizing overall research productivity, increasing capacity to conduct clinical trials, enhancing collaborations, mentoring new researchers, and translating findings into clinical practice and public health settings that will improve health outcomes in persons with HIV and high-risk alcohol comorbidities.