Southern HIV Alcohol Research Consortiium (SHARC) Admin and Research Support Core

描述(由申请人提供)：佛罗里达州是美国艾滋病新诊断率最高的州。其持续流行的特点是明显的种族差距和特殊人口，包括男女性行为者。南方艾滋病毒酒精研究联盟(SHARC)成立于2011年，是一个CHAART，目的是解决高风险饮酒对佛罗里达州艾滋病毒结果的影响。该联盟由三个独立资助的研究项目组成：纳曲酮在高风险饮酒的艾滋病毒感染女性中的随机临床试验，正在进行的专注于酒精对艾滋病毒中神经认知和衰老的影响的队列研究，以及酒精(和纳曲酮)随着时间的推移对免疫衰老的直接影响的免疫学研究。这些项目建立在一个成功的研究基础设施之上，该基础设施已经在佛罗里达州迈阿密招募了800多名艾滋病毒携带者，共享临床研究资源，并有重叠的目标。然而，该联盟缺乏一个中央行政基础设施或机制来支持整个新的研究。SHARC行政和研究支持核心是对RFA-AA-12-010的回应而提交的，对于确保我们的财团项目之间的协调和沟通，形成新的多学科研究合作，以及将我们的研究扩展到佛罗里达州更多的公共卫生机构来说，是至关重要的。这个核心的具体目标是(1)创建一个自给自足的跨学科研究联盟，解决佛罗里达州的艾滋病毒和高风险酒精使用问题(行政核心)；(2)扩大我们的研究和临床试验能力(研究支持)；以及(3)扩大多学科研究并指导新一代科学家(教育)。我们的研究人员带来了临床试验方法学、临床流行病学、免疫学、认知功能、卫生服务研究和锻炼方面的专业知识。总体而言，该核心将通过最大限度地提高整体研究生产率，提高进行临床试验的能力，加强合作，指导新的研究人员，并将研究结果转化为临床实践和公共卫生环境，从而改善艾滋病毒携带者和高风险酒精合并症患者的健康结果，从而支持具有重大影响的研究。

DESCRIPTION (provided by applicant): The State of Florida has the highest rate of new HIV diagnoses in the US. Its ongoing epidemic is characterized by significant racial disparities and special populations including women and men who have sex with men. The Southern HIV Alcohol Research Consortium (SHARC) was created as a CHAART in 2011 to address the impact of high-risk alcohol consumption on HIV outcomes in Florida. The consortium consists of three independently-funded research projects: a randomized clinical trial of naltrexone in HIV-infected women with high-risk drinking, an ongoing cohort study focusing on the impact of alcohol on neurocognition and aging in HIV, and an immunology study of the direct impact of alcohol (and naltrexone) on immune senescence over time. The projects build upon a successful research infrastructure that has already recruited over 800 persons with HIV in Miami, Florida, share clinical research resources, and have overlapping aims. However, the consortium lacks a central administrative infrastructure or mechanism to support new research as a whole. The SHARC Administrative and Research Support Core, submitted in response to RFA-AA-12-010, is critically needed to ensure coordination and communication across our consortium projects, to form new, multidisciplinary research collaborations, and to extend our research into additional public health settings within Florida. The specific aims of this Core are (1) to create a self-sustaining, transdisciplinary research consortium addressing HIV and risky alcohol use in Florida (administrative core); (2) to expand our research and clinical trial capacities (research support); and (3) to expand multidisciplinary research and to mentor a new generation of scientists (education). Our investigators bring expertise in clinical trials methodology, clinical epidemiology, immunology, cognitive function, health services research, and exercise. Overall, the Core will support research that has significant impact by maximizing overall research productivity, increasing capacity to conduct clinical trials, enhancing collaborations, mentoring new researchers, and translating findings into clinical practice and public health settings that will improve health outcomes in persons with HIV and high-risk alcohol comorbidities.