sodium tungstate dihydrate (STD) in Laboratory Animals for the National Toxicolog
sodium tungstate dihydrate (STD) in Laboratory Animals for the National Toxicolog
批准号:
8602486
负责人:
MILTON D HEJTMANCIK
金额:
$69.39万
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-05-01 至 2013-04-30
中文摘要
本项目的目的是评价二水合钨酸钠(STD)通过饮用水暴露于大鼠和小鼠体内的慢性毒性和致癌性。钨是一种高产量的金属,用于各种商业应用,包括军事应用,作为小口径弹药中铅的替代品,以及作为装甲穿甲弹中贫铀的替代品。此外,钨还存在于膳食补充剂中,并具有潜在的临床用途,可用作抗糖尿病治疗。2-性病的慢性毒性和致癌性研究处于活体阶段。
关键词:毒性,致癌性,饮用水,二水钨酸钠
英文摘要
The goal of this project is to evaluate the chronic toxicity and carcinogenicity of sodium tungstate dihydrate (STD) in rats and mice exposed via exposure in drinking water. Tungsten is a high production volume metal that is used in a variety of commercial applications, including military applications as a replacement for lead in small caliber ammunition and as a substitute for depleted uranium in armor penetrators. In addition, tungsten is found in dietary supplements and has potential clinical use as an antidiabetic therapy. 2-Year chronic toxicity and carcinogenicity studies of STD are in the in life phase.
Keywords: toxicity, carcinogenicity, drinking water, sodium tungstate dihydrate
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