Conduct of studies to evaluate the toxic and carcinogenic potential of sulfolane in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估环丁砜对实验动物的毒性和致癌潜力

• 批准号: 9162301
• 负责人: MILTON D HEJTMANCIK
• 金额: $ 252.62万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2015-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9162301
• 关键词: Alaska; Animals; Chemicals; Chronic; Development; Goals; Human; Laboratory Animals; Life; Mus; National Toxicology Program; Phase; Rattus; Risk; Toxic effect; Toxicity Tests; carcinogenicity; drinking water; ground water; hazard; immunotoxicity

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of sulfolane in rats and mice, following exposure in drinking water. There are concerns over the potential toxicity of sulfolane following exposure in contaminated ground water, particularly in Alaska. 2-Year chronic toxicity and carcinogenicity studies of sulfolane are in the in life phase. These studies include an assessment of developmental landmarks, subchronic toxicity and immunotoxicity. Keywords: toxicity, carcinogenicity, drinking water, sulfolane

该项目的目标是评估大鼠和小鼠在饮用水中接触环丁砜后的慢性毒性和致癌性。人们担心环丁砜在接触受污染的地下水后可能产生毒性，特别是在阿拉斯加。2-年环丁砜的慢性毒性和致癌性研究处于活体阶段。这些研究包括对发育标志、亚慢性毒性和免疫毒性的评估。 关键词：毒性，致癌性，饮用水，环丁砜