toxic and carcinogenic potential of alpha-pinene in laboratory animals for the National Toxicology Program (NTP)

国家毒理学计划 (NTP) 的实验动物中 α-蒎烯的毒性和致癌潜力

• 批准号: 8948077
• 负责人: MILTON D HEJTMANCIK
• 金额: $ 107.83万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2015-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8948077
• 关键词: Animals; Breathing; Chemicals; Chemistry; Chronic; Engineering; Fertility; Flavoring; Goals; Human; Inhalation Exposure; Laboratory Animals; Mus; National Toxicology Program; Phase; Process; Rattus; Self Care; Sperm Count Procedure; Sperm Motility; System; Toxic effect; Toxicity Tests; Turpentine; alpha-pinene; carcinogenicity; hazard; male; reproductive

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of alpha-pinene in rats and mice, following whole body inhalation exposure. Alpha-pinene is found in turpentine and in flavorings and fragrances. Humans may be exposed through use of personal care and cleaning products as well as in lumber processing and building activities. 2-Year chronic toxicity and carcinogenicity studies of alpha-pinene are in the chemistry and inhalation exposure system engineering phase phase. These studies include an assessment of fertility and sperm count and motility, as male reproductive effects are anticipated. Keywords: toxicity, carcinogenicity, inhalation, alpha-pinene

本项目的目的是评估α -蒎烯在大鼠和小鼠全身吸入暴露后的慢性毒性和致癌性。-蒎烯存在于松节油和香料中。人类可能通过使用个人护理和清洁产品以及木材加工和建筑活动接触到这种物质。2年的α -蒎烯慢性毒性和致癌性研究正处于化学和吸入暴露系统工程阶段。这些研究包括对生育能力、精子数量和活力的评估，因为男性生殖影响是预期的。