Conduct of studies to evaluate the toxic and potential of vanadyl sulfate and sodium metavanadate in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估硫酸氧钒和偏钒酸钠对实验动物的毒性和潜力

• 批准号: 9162299
• 负责人: MILTON D HEJTMANCIK
• 金额: $ 100万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2015-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9162299
• 关键词: Animals; Chemicals; Chronic; Data; Development; Goals; Human; Laboratory Animals; National Toxicology Program; Risk; Sodium; Toxic effect; Toxicity Tests; Vanadium; Vanadium Compounds; carcinogenicity; design; drinking water; hazard; reproductive; vanadyl sulfate

The goal of this project is to evaluate the toxicity of pentavalent (sodium metavanadate) and tetravalent (vanadyl sulfate) vanadium compounds, following exposure in drinking water. Two-week studies of both compounds have been completed recently; subchronic studies are currently being designed by NTP. Humans are likely to be similarly exposed to these compounds in drinking water. As there are little available toxicity data on these compounds, these short-term studies provide valuable data to design more definitive reproductive/developmental and chronic toxicity/carcinogenicity studies. In addition, the 2-week studies were designed similarly to allow comparisons of the toxicity between pentavalent and tetravalent vanadium. Keywords: toxicity, drinking water, vanadium, pentavalent, tetravalent, vanadyl sulfate, sodium metavanadate.

本项目的目标是评估五价（偏钒酸钠）和四价（硫酸氧钒）钒化合物暴露于饮用水后的毒性。最近完成了对这两种化合物的为期两周的研究; NTP目前正在设计亚慢性研究。人类也可能在饮用水中暴露于这些化合物。由于这些化合物的可用毒性数据很少，这些短期研究为设计更明确的生殖/发育和慢性毒性/致癌性研究提供了有价值的数据。此外，2周研究的设计类似，以比较五价和四价钒之间的毒性。 关键词：毒性，饮用水，钒，五价，四价，硫酸氧钒，偏钒酸钠。