toxic and potential of vanadyl sulfate and sodium metavanadate in laboratory animals for the National Toxicology Program (NTP)

本项目的目标是评估五价（偏钒酸钠）和四价（硫酸氧钒）钒化合物暴露于饮用水后的毒性。对这两种化合物的为期两周的研究正处于生命阶段。人类也可能在饮用水中暴露于这些化合物。由于这些化合物的可用毒性数据很少，这些短期研究为设计更明确的生殖/发育和慢性毒性/致癌性研究提供了有价值的数据。此外，2周研究的设计类似，以比较五价和四价钒之间的毒性。 关键词：毒性，饮用水，钒，五价，四价，硫酸氧钒，偏钒酸钠。

The goal of this project is to evaluate the toxicity of pentavalent (sodium metavanadate) and tetravalent (vanadyl sulfate) vanadium compounds, following exposure in drinking water. Two-week studies of both compounds are in the in life phase. Humans are likely to be similarly exposed to these compounds in drinking water. As there are little available toxicity data on these compounds, these short-term studies provide valuable data to design more definitive reproductive/developmental and chronic toxicity/carcinogenicity studies. In addition, the 2-week studies were designed similarly to allow comparisons of the toxicity between pentavalent and tetravalent vanadium. Keywords: toxicity, drinking water, vanadium, pentavalent, tetravalent, vanadyl sulfate, sodium metavanadate.