TAS::75 0862::TAS STUDIES TO EVALUATE TOXIC AND CARCINOGENIC POTENTIAL OF TEST A

本项目的目的是评估两种邻苯二甲酸酯增塑剂，邻苯二甲酸二丁酯（DBP）和邻苯二甲酸二（2-乙基己基）酯（DEHP）在饮食暴露后的慢性毒性和致癌性。DBP和DEHP的2年慢性毒性和致癌性研究正处于生命期。这两项研究都包括围产期暴露（妊娠和哺乳期暴露）。人类很可能同样通过环境接触到这些化合物。围产期接触发生在发育的关键时期，与仅从成年期开始接触相比，可能导致毒性/致癌性的差异。在DBP研究中，大鼠在开始为期2年的研究之前是围产期暴露的，而标准研究正在小鼠中进行。DEHP包括两项为期两年的大鼠研究，一项有围产期暴露，另一项没有，以评估围产期暴露的影响。

The goal of this project is to evaluate the chronic toxicity and carcinogenicity of two phthalate plasticizers, dibutyl phthalate (DBP) and di(2-ethylhexyl)phthalate (DEHP), following dietary exposures. 2-Year chronic toxicity and carcinogenicity studies of DBP and DEHP are in the in life phase. Both of these studies include perinatal exposures (exposure during gestation and lactation). Humans are likely to be similarly exposed to these compounds through the environment. Perinatal exposure occurs during critical periods of development and can result in differences in toxicity/carcinogenicity as compared to exposure starting only from adulthood. In the DBP study, rats were exposed perinatally prior to the start of 2-year study, while standard studies are being conducted in mice. DEHP includes two 2-year rat studies, one with perinatal exposure and one without, to evaluate the effect of perinatal exposure. Keywords: toxicity, carcinogenicity, diet, perinatal, phthalate, dibutyl phthalate, di(2-ethylhexyl)phthalate.