Conduct of studies to evaluate the toxic and carcinogenic potential of naturally occurring asbestos in laboratory animals for the National Toxicology Program (NTP)

为国家毒理学计划 (NTP) 开展研究，评估实验动物中天然存在的石棉的毒性和致癌潜力

• 批准号: 9162302
• 负责人: MILTON D HEJTMANCIK
• 金额: $ 100万
• 依托单位: BATTELLE MEMORIAL INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2015-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9162302
• 关键词: Animals; Asbestos; Breathing; Chemicals; Data; Dose; Fiber; Goals; Human; Inhalation Exposure; Laboratory Animals; Methods; National Toxicology Program; Preparation; Research Design; Risk; Tissues; Toxic effect; Toxicity Tests; Work; carcinogenicity; design; hazard; method development; response

The goal of this project is to develop inhalation exposure and tissue burden preparation and analysis methods to facilitate the NTPs designing of toxicity and carcinogenicity studies of naturally occurring asbestos. There is a need to generate high quality, dose response data on different types of asbestos fibers. However, there are numerous methodological challenges that need to be resolved prior to finalization of the design of these studies. Method development work is currently in progress. Keywords: toxicity, carcinogenicity, asbestos, inhalation, fiber

该项目的目标是开发吸入暴露和组织负荷制备和分析方法，以促进自然产生的石棉的毒性和致癌性研究的NTPs设计。需要在不同类型的石棉纤维上生成高质量的剂量响应数据。然而，在最终确定这些研究的设计之前，有许多方法上的挑战需要解决。方法开发工作目前正在进行中。 关键词：毒性、致癌性、石棉、吸入、纤维