2012 CSHL Nuclear Receptors & Disease Conference

描述（由申请人提供）：冷泉港实验室会议核受体和疾病2012年10月30日至11月3日项目摘要本提案寻求对将于2012年10月30日至11月3日在冷泉港实验室举行的“核受体和疾病”会议的支持。会议将汇集该领域的领导者，与初级教师，博士后研究员和研究生一起，讨论我们对核受体的生理和细胞功能以及它们在人类疾病中的作用的理解的最新进展。 核受体是与DNA结合并响应于与受体结合的小“信使”分子而调节基因表达的蛋白质。通过这种信使-受体系统，关于细胞的环境和代谢状况的重要信息被传递到基因组，从而导致基因表达的变化。这些受体作为细胞生长、分化和代谢的调节剂起着非常重要的作用，并且这些受体的失调可导致代谢疾病和不同类型的癌症。 会议将涵盖广泛的主题，从详细的分子作用机制到生物体水平的临床意义。每次会议将由该领域的一位顶尖科学家主持。将由一组杰出的特邀演讲者以及从提交的摘要中选出的演讲者作口头介绍。选定的演讲者将包括研究生，博士后研究员和初级教师，旨在最大限度地纳入年轻的研究人员。特别重要的是两次海报会议，许多与会者可以在有利于非正式讨论的气氛中介绍他们的工作。会议将是中等规模，我们预计约有250人参加，其中绝大多数将提交海报或演讲。 公共卫生相关性：核受体与疾病核受体是我们细胞中的重要蛋白质，它与小的化学信使结合，并通过与DNA结合并以特定方式调节遗传信息的表达来解释这些个体信号。这些蛋白质控制细胞的生长、代谢和命运，并且这些受体的功能障碍或失调可导致代谢疾病（例如肥胖症、糖尿病和心血管疾病）和不同类型的癌症（例如乳腺癌和前列腺癌）。了解核受体的基本活性以及这些受体如何被破坏，对于我们理解和治疗这些疾病的能力非常重要。为了给从事核受体不同方面工作的基础和临床研究人员提供一个交流的场所，我们建议于2012年11月在冷泉港实验室举行一次题为“核受体与疾病”的会议。

DESCRIPTION (provided by applicant): Cold Spring Harbor Laboratory Conference on Nuclear Receptors and Disease October 30 - November 3, 2012 Project Summary This proposal seeks support for the meeting on "Nuclear Receptors and Disease" to be held at Cold Spring Harbor Laboratory October 30 - November 3, 2012. The meeting will assemble leaders in the field, together with junior faculty, postdoctoral fellows and graduate students, to discuss the latest advances in our understanding of the physiological and cellular function of nuclear receptors as well as their role in human diseases. Nuclear receptors are proteins that bind to DNA and regulate gene expression in response to small "messenger" molecules that bind to the receptors. By means of this messenger-receptor system important information about the environment and the metabolic condition of the cell is communicated to the genome thereby leading to changes in gene expression. These receptors play very important roles as regulators of cellular growth, differentiation and metabolism, and dysregulation of these receptors can lead to metabolic diseases and different types of cancer. The meeting will cover a broad spectrum of topics ranging from detailed molecular mechanism of action to clinical implications at the organismal level. Each session will be chaired by a leading scientist in the field. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include graduate students, postdoctoral fellows and junior faculty aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants can present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size and we expect about 250 people to attend, the vast majority of whom will be presenting a poster or talk. PUBLIC HEALTH RELEVANCE: Nuclear Receptors and Disease PROJECT NARRATIVE Nuclear receptors are important proteins in our cells which bind to small chemical messengers and interpret these individual signals by binding to DNA and regulating the expression of genetic information in specific ways. These proteins control the growth, metabolism and fate of cells, and malfunction or dysregulation of these receptors can lead to metabolic diseases (e.g. obesity, diabetes and cardiovascular diseases) and to different types of cancer (e.g. breast and prostate cancer). Understanding the basic activity of nuclear receptors and how these may become disrupted is of great importance for our ability to understand and treat these diseases. To provide a venue for interaction between basic and clinical researchers working on different aspects of nuclear receptors, we propose to hold a meeting entitled Nuclear Receptors and Disease at Cold Spring Harbor Laboratory in November 2012.