COBRE Center for Neurodegenerative Disorder Research

描述（由申请人提供）：神经退行性疾病研究是三份独立的战略研究报告中确定的UND为数不多的公认优势之一。这项COBRE 111期资金申请将支持我们神经退行性疾病研究小组的行政核心、试点资助计划以及我们的质谱和成像核心。我们的COBRE小组继续专注于确定神经退行性疾病的发病机制和确定可能的治疗干预措施。自从我们的COBRE基金在9年前启动以来，我们支持了11个项目主管，我们开发并支持了两个核心，我们支持雇用了9名神经科学教师，我们用试点资金支持了16名神经科学研究者。COBRE的研究人员获得了大约1100万美元的校外资助，发表了242篇手稿，并建造了一座新的神经科学研究大楼。我们的质谱核心设备几乎完全用于小分子分析，包括代谢组学，脂质组学，药物代谢，分子结构鉴定和小分子定量。我们的设备包括一个新的Waters Synapt G2 QTOF (UPLC和Nanomate)，一个API-3000三重四极柱（HPLC），一个QSTAR (nanoLC)，一个Polaris Q离子阱（GC）和一个Beckman 2-D HPLC。我们的成像核心设施提供访问荧光，共聚焦，多光子和电子显微镜仪器。我们的设备包括两台共聚焦显微镜（蔡司510 META LSCM，奥林巴斯FV300 LSCM），一台蔡司ConfoCor2荧光相关光谱单元，一台奥林巴斯FV1000MPE基本多光子/可见共聚焦显微镜系统，以及两台荧光显微镜（配备FURA2和CFP/YFP FRET比例成像的尼康TE300，以及一台尼康Eclipse 801）。电子显微镜方面，我们有扫描电子显微镜（日立4700）和透射电子显微镜（日立7500），Reichert超显微切片仪，以及一系列辅助设备。COBRE资助的神经退行性疾病研究小组得到了联合国开发计划署的大力支持，我们的成功得到了联合国开发计划署的认可，联合国开发计划署完全致力于在COBRE资助结束后帮助维持我们的努力。

DESCRIPTION (provided by applicant): Neurodegenerative disease research is one of UND's few recognized strengths as identified in 3 separate Strategic research reports. This COBRE Phase 111 funding request will support our neurodegenerative disease research group's administrative core, pilot grant program, and our mass spectrometry and imaging cores. Our COBRE group continues to focus on determining mechanisms responsible for the pathogenesis of and identifying possible therapeutic interventions against neurodegenerative disorders. Since our COBRE funding started 9 years ago, we supported 11 project directors, we developed and supported two cores, we supported the hiring of 9 neuroscience faculty, and we supported with pilot grants 16 neuroscience investigators. COBRE investigators received about $11M in extramural grants, published 242 manuscripts, and a new Neuroscience Research Building was built. Our Mass Spectrometry Core Facility is used almost exclusively for small molecule analysis including metabolomics, lipidomics, drug metabolism, molecule structure identification, and small molecule quantification. The equipment housed in our facility includes a new Waters Synapt G2 QTOF with UPLC and Nanomate, an API-3000 triple quadripole with HPLC, a QSTAR with nanoLC, a Polaris Q ion trap with GC, and a Beckman 2-D HPLC. Our Imaging Core Facility provides access to fluorescence, confocal, multiphoton, and electron microscopy instrumentation. The equipment housed in our facility includes two confocal microscopes (Zeiss 510 META LSCM, Olympus FV300 LSCM), a Zeiss ConfoCor2 fluorescence correlation spectroscopy unit, an Olympus FV1000MPE Basic multiphoton/visible confocal microscope system, and two fluorescence microscopes (Nikon TE300 equipped for FURA2 and CFP/YFP FRET ratiometric imaging, and a Nikon Eclipse 801). For electron microscopy, we have a scanning (Hitachi 4700) and a transmission (Hitachi 7500) electron microscope, Reichert ultra-microtomes, and a range of ancillary equipment. The COBRE grant-supported neurodegenerative disease research group has been supported strongly by UND, our successes are recognized by UND, and UND is fully committed to helping sustain our efforts after COBRE funding ends.