COBRE Center for Neurodegenerative Disorder Research

描述(由申请人提供)：神经退行性疾病研究是UND在3份独立的战略研究报告中确定的为数不多的公认优势之一。这项Cobre第111期资金申请将支持我们的神经退行性疾病研究小组的管理核心、试点拨款计划以及我们的质谱学和成像核心。我们的Cobre小组继续专注于确定神经退行性疾病的发病机制，并确定可能的治疗干预措施。自从我们的Cobre基金在9年前开始以来，我们支持了11个项目主任，我们开发和支持了两个核心，我们支持了9名神经科学教师的招聘，我们用试点拨款支持了16名神经科学研究人员。科布雷的研究人员收到了大约1100万美元的校外拨款，发表了242篇手稿，并建造了一座新的神经科学研究大楼。我们的质谱学核心设备几乎完全用于小分子分析，包括代谢组学、脂类组学、药物代谢、分子结构鉴定和小分子定量。我们设施中安装的设备包括配备UPLC和Nanomate的新Waters Synapt G2 QTOF，配备高效液相的API-3000三重四极杆，配备NanoLC的QSTAR，配备GC的Polaris Q离子捕捉器，以及Beckman二维高效液相色谱仪。我们的成像核心设备提供荧光、共焦、多光子和电子显微镜仪器。我们设施中的设备包括两台共焦显微镜(蔡司510 META LSCM，奥林巴斯FV300 LSCM)，一台蔡司ConfoCor2荧光相关光谱仪，一台奥林巴斯FV1000MPE基本多光子/可见光共焦显微镜系统，以及两台荧光显微镜(尼康TE300，配备用于FURA2和CFP/YFP FRET比率成像，以及一台尼康Eclipse 801)。对于电子显微镜，我们有扫描(日立4700)和透射式(日立7500)电子显微镜、Reichert超显微显微镜和一系列辅助设备。科布雷资助的神经退行性疾病研究小组得到了联合国开发计划署的大力支持，我们的成功得到了联合国开发计划署的认可，联合国开发计划署完全致力于在科布雷资助结束后帮助我们继续努力。

DESCRIPTION (provided by applicant): Neurodegenerative disease research is one of UND's few recognized strengths as identified in 3 separate Strategic research reports. This COBRE Phase 111 funding request will support our neurodegenerative disease research group's administrative core, pilot grant program, and our mass spectrometry and imaging cores. Our COBRE group continues to focus on determining mechanisms responsible for the pathogenesis of and identifying possible therapeutic interventions against neurodegenerative disorders. Since our COBRE funding started 9 years ago, we supported 11 project directors, we developed and supported two cores, we supported the hiring of 9 neuroscience faculty, and we supported with pilot grants 16 neuroscience investigators. COBRE investigators received about $11M in extramural grants, published 242 manuscripts, and a new Neuroscience Research Building was built. Our Mass Spectrometry Core Facility is used almost exclusively for small molecule analysis including metabolomics, lipidomics, drug metabolism, molecule structure identification, and small molecule quantification. The equipment housed in our facility includes a new Waters Synapt G2 QTOF with UPLC and Nanomate, an API-3000 triple quadripole with HPLC, a QSTAR with nanoLC, a Polaris Q ion trap with GC, and a Beckman 2-D HPLC. Our Imaging Core Facility provides access to fluorescence, confocal, multiphoton, and electron microscopy instrumentation. The equipment housed in our facility includes two confocal microscopes (Zeiss 510 META LSCM, Olympus FV300 LSCM), a Zeiss ConfoCor2 fluorescence correlation spectroscopy unit, an Olympus FV1000MPE Basic multiphoton/visible confocal microscope system, and two fluorescence microscopes (Nikon TE300 equipped for FURA2 and CFP/YFP FRET ratiometric imaging, and a Nikon Eclipse 801). For electron microscopy, we have a scanning (Hitachi 4700) and a transmission (Hitachi 7500) electron microscope, Reichert ultra-microtomes, and a range of ancillary equipment. The COBRE grant-supported neurodegenerative disease research group has been supported strongly by UND, our successes are recognized by UND, and UND is fully committed to helping sustain our efforts after COBRE funding ends.