COBRE Center for Neurodegenerative Disorder Research

COBRE 神经退行性疾病研究中心

• 批准号: 8305248
• 负责人: Jonathan David Geiger
• 金额: $ 102.83万
• 依托单位: UNIVERSITY OF NORTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-07-15 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8305248
• 关键词: Accounting; Advisory Committees; Anatomy; Cellular biology; Centers of Research Excellence; Commit; Communities; Confocal Microscopy; Core Facility; Data; Electron Microscope; Electron Microscopy; Ensure; Equipment; Extramural Activities; Faculty; Fluorescence; Fluorescence Resonance Energy Transfer; Fostering; Functional disorder; Funding; Future; Grant; Health Science Library; Health Sciences; High Pressure Liquid Chromatography; Housing; Image; Image Analysis; Ions; Libraries; Life; Literature; Manuscripts; Mass Spectrum Analysis; Measures; Mentors; Mentorship; Microscope; Microtome - medical device; Molecular Weight; National Center for Research Resources; Neurodegenerative Disorders; Neurosciences; Neurosciences Research; North Dakota; Pathogenesis; Pharmacology; Phase; Physiology; Positioning Attribute; Principal Investigator; Publishing; Recruitment Activity; Reporting; Research; Research Personnel; Scanning; Series; Spectrum Analysis; Structure; System; Therapeutic; Therapeutic Intervention; Universities; Visit; Water; cost; drug metabolism; fluorescence microscope; instrumentation; light microscopy; mass spectrometer; medical schools; meetings; member; metabolomics; microbial alkaline proteinase inhibitor; professor; programs; ratiometric; small molecule; success; symposium; transmission process; two-photon

DESCRIPTION (provided by applicant): Neurodegenerative disease research is one of UND's few recognized strengths as identified in 3 separate Strategic research reports. This COBRE Phase 111 funding request will support our neurodegenerative disease research group's administrative core, pilot grant program, and our mass spectrometry and imaging cores. Our COBRE group continues to focus on determining mechanisms responsible for the pathogenesis of and identifying possible therapeutic interventions against neurodegenerative disorders. Since our COBRE funding started 9 years ago, we supported 11 project directors, we developed and supported two cores, we supported the hiring of 9 neuroscience faculty, and we supported with pilot grants 16 neuroscience investigators. COBRE investigators received about $11M in extramural grants, published 242 manuscripts, and a new Neuroscience Research Building was built. Our Mass Spectrometry Core Facility is used almost exclusively for small molecule analysis including metabolomics, lipidomics, drug metabolism, molecule structure identification, and small molecule quantification. The equipment housed in our facility includes a new Waters Synapt G2 QTOF with UPLC and Nanomate, an API-3000 triple quadripole with HPLC, a QSTAR with nanoLC, a Polaris Q ion trap with GC, and a Beckman 2-D HPLC. Our Imaging Core Facility provides access to fluorescence, confocal, multiphoton, and electron microscopy instrumentation. The equipment housed in our facility includes two confocal microscopes (Zeiss 510 META LSCM, Olympus FV300 LSCM), a Zeiss ConfoCor2 fluorescence correlation spectroscopy unit, an Olympus FV1000MPE Basic multiphoton/visible confocal microscope system, and two fluorescence microscopes (Nikon TE300 equipped for FURA2 and CFP/YFP FRET ratiometric imaging, and a Nikon Eclipse 801). For electron microscopy, we have a scanning (Hitachi 4700) and a transmission (Hitachi 7500) electron microscope, Reichert ultra-microtomes, and a range of ancillary equipment. The COBRE grant-supported neurodegenerative disease research group has been supported strongly by UND, our successes are recognized by UND, and UND is fully committed to helping sustain our efforts after COBRE funding ends. PUBLIC HEALTH RELEVANCE (provided by applicant): COBRE Phase III funding will (1) support 2 cores essential to our neuroscience COBRE group as well as other biomedical researchers, (2) support our pilot grant program that enables investigators to generate data necessary for getting their respective grants funded, and (3) support our administrative core that provides for centralized ordering, a visiting speaker program, library acquisitions, and an annual neuroscience symposium. UND is fully committed to ensuring the sustainability of this group after the COBRE grant ends.

描述（由申请人提供）：神经退行性疾病研究是UND为数不多的公认优势之一，在3份独立的战略研究报告中得到了确认。COBRE第111期资金申请将支持我们的神经退行性疾病研究小组的行政核心，试点资助计划以及我们的质谱和成像核心。我们的COBRE小组继续专注于确定负责神经退行性疾病发病机制的机制，并确定可能的治疗干预措施。自9年前COBRE基金启动以来，我们支持了11位项目负责人，开发和支持了两个核心，支持了9名神经科学教师的招聘，并为16名神经科学研究人员提供了试点赠款。COBRE研究人员获得了约1100万美元的校外赠款，出版了242篇手稿，并建造了一座新的神经科学研究大楼。我们的质谱核心设施几乎专门用于小分子分析，包括代谢组学，脂质组学，药物代谢，分子结构鉴定和小分子定量。我们机构中的设备包括配备UPLC和Nanomate的新型沃茨Synapt G2 QTOF、配备HPLC的API-3000三重四极杆、配备nanoLC的QSTAR、配备GC的Polaris Q离子阱和Beckman 2-D HPLC。我们的成像核心设施提供荧光，共聚焦，多光子和电子显微镜仪器。在我们的设施中容纳的设备包括两个共聚焦显微镜（Zeiss 510 Meta LSCM、Olympus FV 300 LSCM）、Zeiss ConfoCor 2荧光相关光谱单元、Olympus FV 1000 MPE Basic多光子/可见光共聚焦显微镜系统和两个荧光显微镜（Nikon TE 300配备用于FURA 2和CFP/YFP FRET比率成像，以及Nikon Eclipse 801）。对于电子显微镜，我们有扫描（Hitachi 4700）和透射（Hitachi 7500）电子显微镜，Reichert超薄切片机和一系列辅助设备。COBRE资助的神经退行性疾病研究小组得到了UND的大力支持，我们的成功得到了UND的认可，UND完全致力于在COBRE资助结束后帮助维持我们的努力。 公共卫生相关性（申请人提供）：COBRE第三阶段资金将（1）支持我们的神经科学COBRE小组以及其他生物医学研究人员所必需的2个核心，（2）支持我们的试点资助计划，使研究人员能够生成获得各自赠款所需的数据，以及（3）支持我们的行政核心，提供集中订购，访问演讲者计划，图书馆藏书和年度神经科学研讨会UND完全致力于确保在COBRE赠款结束后这一群体的可持续性。