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COBRE Center for Neurodegenerative Disorder Research

COBRE 神经退行性疾病研究中心

基本信息

批准号：
9068160
负责人：
Jonathan David Geiger
金额：
$ 102.83万
依托单位：
UNIVERSITY OF NORTH DAKOTA
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-07-15 至 2018-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9068160
关键词：
Accounting Advisory Committees Anatomy Cellular biology Centers of Research Excellence Communities Confocal Microscopy Core Facility Data Department chair Electron Microscope Electron Microscopy Ensure Equipment Extramural Activities Faculty Fluorescence Fluorescence Resonance Energy Transfer Fostering Functional disorder Funding Future Teacher Grant Health Science Library Health Sciences High Pressure Liquid Chromatography Housing Image Image Analysis Ions Libraries Life Literature Manuscripts Mass Spectrum Analysis Measures Mentors Mentorship Microscope Microtome - medical device Molecular Weight National Center for Research Resources Neurodegenerative Disorders Neurosciences Neurosciences Research North Dakota Pathogenesis Pharmacology Phase Physiology Positioning Attribute Principal Investigator Publishing Recruitment Activity Reporting Research Research Personnel Scanning Series Spectrum Analysis Structure System Therapeutic Therapeutic Intervention Universities Visit Water cost distinguished professor drug metabolism faculty support fluorescence microscope instrumentation light microscopy mass spectrometer medical schools meetings member metabolomics professor programs ratiometric small molecule success symposium transmission process two-photon

项目摘要

DESCRIPTION (provided by applicant): Neurodegenerative disease research is one of UND's few recognized strengths as identified in 3 separate Strategic research reports. This COBRE Phase 111 funding request will support our neurodegenerative disease research group's administrative core, pilot grant program, and our mass spectrometry and imaging cores. Our COBRE group continues to focus on determining mechanisms responsible for the pathogenesis of and identifying possible therapeutic interventions against neurodegenerative disorders. Since our COBRE funding started 9 years ago, we supported 11 project directors, we developed and supported two cores, we supported the hiring of 9 neuroscience faculty, and we supported with pilot grants 16 neuroscience investigators. COBRE investigators received about $11M in extramural grants, published 242 manuscripts, and a new Neuroscience Research Building was built. Our Mass Spectrometry Core Facility is used almost exclusively for small molecule analysis including metabolomics, lipidomics, drug metabolism, molecule structure identification, and small molecule quantification. The equipment housed in our facility includes a new Waters Synapt G2 QTOF with UPLC and Nanomate, an API-3000 triple quadripole with HPLC, a QSTAR with nanoLC, a Polaris Q ion trap with GC, and a Beckman 2-D HPLC. Our Imaging Core Facility provides access to fluorescence, confocal, multiphoton, and electron microscopy instrumentation. The equipment housed in our facility includes two confocal microscopes (Zeiss 510 META LSCM, Olympus FV300 LSCM), a Zeiss ConfoCor2 fluorescence correlation spectroscopy unit, an Olympus FV1000MPE Basic multiphoton/visible confocal microscope system, and two fluorescence microscopes (Nikon TE300 equipped for FURA2 and CFP/YFP FRET ratiometric imaging, and a Nikon Eclipse 801). For electron microscopy, we have a scanning (Hitachi 4700) and a transmission (Hitachi 7500) electron microscope, Reichert ultra-microtomes, and a range of ancillary equipment. The COBRE grant-supported neurodegenerative disease research group has been supported strongly by UND, our successes are recognized by UND, and UND is fully committed to helping sustain our efforts after COBRE funding ends.

描述（由申请人提供）：神经退行性疾病研究是 UND 为数不多的公认优势之一，这在 3 份独立的战略研究报告中得到了确定。 COBRE 111 期资金请求将支持我们的神经退行性疾病研究小组的行政核心、试点资助计划以及我们的质谱和成像核心。我们的 COBRE 小组继续专注于确定神经退行性疾病的发病机制并确定可能的治疗干预措施。自 9 年前开始提供 COBRE 资助以来，我们支持了 11 名项目主管，开发并支持了两个核心项目，支持聘用 9 名神经科学教员，并为 16 名神经科学研究人员提供了试点资助。 COBRE 研究人员获得了约 1100 万美元的外部资助，发表了 242 份手稿，并建造了一座新的神经科学研究大楼。我们的质谱核心设施几乎专门用于小分子分析，包括代谢组学、脂质组学、药物代谢、分子结构鉴定和小分子定量。我们设施中的设备包括配备 UPLC 和 Nanomate 的新型 Waters Synapt G2 QTOF、配备 HPLC 的 API-3000 三重四极杆、配备 nanoLC 的 QSTAR、配备 GC 的 Polaris Q 离子阱和 Beckman 2-D HPLC。我们的成像核心设施提供荧光、共焦、多光子和电子显微镜仪器。我们设施中的设备包括两台共焦显微镜（Zeiss 510 META LSCM、Olympus FV300 LSCM）、一台 Zeiss ConfoCor2 荧光相关光谱仪、一台 Olympus FV1000MPE 基本多光子/可见光共焦显微镜系统和两台荧光显微镜（配备用于 FURA2 和 FURA2 的 Nikon TE300） CFP/YFP FRET 比例成像和 Nikon Eclipse 801）。对于电子显微镜，我们拥有扫描 (Hitachi 4700) 和透射 (Hitachi 7500) 电子显微镜、Reichert 超薄切片机以及一系列辅助设备。 COBRE 资助的神经退行性疾病研究小组得到了 UND 的大力支持，我们的成功得到了 UND 的认可，UND 完全致力于在 COBRE 资助结束后帮助维持我们的努力。