Protein Core

蛋白质核心设施是华盛顿大学风湿病核心中心(RDCC)的研究核心之一。它提出了以下具体目标，以维持和发展向RDCC成员提供的新的最先进的蛋白质服务：1)支持杂交瘤中心的持续进步和增长；以及2)支持蛋白质生产和纯化设施的持续进步和增长。杂交瘤中心协助RDCC研究人员产生分泌对当代免疫学和风湿病研究至关重要的单抗的原代杂交瘤。例如，正在测试为RDCC调查人员提供兔单抗和基因免疫的新服务。蛋白质生产和纯化设施帮助RDCC研究人员为他们的研究生产和纯化大量的单抗。此外，它最近还获得了从一些不同的表达系统中生产和纯化重组蛋白和天然蛋白的专业知识。这项服务现在将向RDCC社区提供。

The Protein Core facility is one of the research cores in the Rheumatic Diseases Core Center (RDCC) at Washington University. It proposes the following Specific Aims to sustain and develop new state-of-the-art protein services to RDCC members: 1) Support continued progress and growth of the Hybridoma Center; and 2) Support continued progress and growth of the Protein Production and Purification Facility. The Hybridoma Center aids RDCC investigators in the generation of primary hybridomas secreting monoclonal antibodies that are critical to contemporary immunology and rheumatic diseases research. New services are being tested to offer RDCC investigators rabbit monoclonal antibodies and genetic immunization, for example. The Protein Production and Purification Facility aids RDCC investigators by producing and purifying large quantities of monoclonal antibodies for their studies. In addition, it has recently gained expertise in producing and purifying recombinant and native proteins from a number of different expression systems. This service will now be made available to the RDCC community.