Environmental Factors in Cardiovascular Disease

心血管疾病的环境因素

• 批准号: 8462602
• 负责人: Joel Daniel Kaufman
• 金额: $ 14.1万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8462602
• 关键词: Acetylcysteine; Acute; Address; Air; Air Pollutants; Air Pollution; Antioxidants; Atherosclerosis; Attenuated; Award; Biometry; Blood Vessels; Breathing; Caliber; Carbon Black; Cardiology; Cardiovascular Diseases; Cardiovascular system; Carotid Arteries; Chronic; Clinical; Collaborations; CpG Islands; DNA Methylation; Data Analyses; Databases; Diesel Exhaust; Discipline; Endothelin-1; Environmental Engineering technology; Environmental Health; Environmental Medicine; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Exposure to; Funding; Genes; Genetic Polymorphism; Genome; Goals; Grant; Health; Homeostasis; Hour; Human; Hygiene; Incidence; Individual; Inflammation; Intention; Interleukin-6; Joints; Kinetics; Left; Long-Term Effects; Measures; Medial; Mediating; Mediator of activation protein; Medical Students; Mentors; Mentorship; Methylation; Mid-Career Clinical Scientist Award (K24); Modeling; Morbidity - disease rate; NIH Program Announcements; Occupational; Occupational Medicine; Oxidative Stress; Participant; Particulate; Particulate Matter; Pathway interactions; Plasma; Play; Pollution; Prevalence; Productivity; Public Health; Public Policy; Pulmonology; Receptor, Angiotensin, Type 1; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Retinal; Role; Sampling; Site; Source; Specific qualifier value; Staging; Structure; Students; Supplementation; Thick; Time; Toxicology; Training; Training Programs; Translational Research; Ultrasonography; Universities; Vascular System; Washington; X-Ray Computed Tomography; ascorbate; base; cardiovascular disorder epidemiology; clinical practice; cohort; coronary artery calcification; cytokine; epigenomics; exposed human population; graduate student; health science research; monocyte; mortality; patient oriented; patient oriented research; pollutant; population based; programs; prospective; public health relevance; research study; success; time use; trafficking; translational approach; vasoconstriction

DESCRIPTION (provided by applicant) The goal of this proposed midcareer investigator award is to expand training in multi- disciplinary research focused on the environmental health sciences at the University of Washington. Through collaborations with several ongoing training programs, the candidate, Joel D. Kaufman, MD, MPH, will extend a broad research program and mentoring program with trainees from several relevant disciplines. During the initial K24 award period, Dr. Kaufman's research productivity and mentorship increased and accelerated in depth and breadth. This continuing program will integrate experimental, epidemiologic, and translational approaches to the role of environmental factors in cardiovascular disease. The proposed research is a combination of two thematically related projects from Dr. Kaufman's ongoing research program. Both address the thesis that traffic-related air pollution exerts an effect on cardiovascular diseases through acute and chronic impacts on the vascular system. One project studies the effect of diesel exhaust inhalation on vascular function in controlled exposures, addressing mechanistic hypotheses to understand the role of oxidative stress. The second project is based in an epidemiological study of air pollution effects on cardiovascular disease, and examines the joint and independent effects of acute and chronic pollution exposures on vascular function, atherosclerosis, and epigenomic markers, in a multi-ethnic population-based cohort. The mentorship program builds on Dr. Kaufman's success in multi-disciplinary research, and aims to provide research mentorship in patient-oriented environmental health sciences research to trainees from a wide variety of disciplines. These will include fellows in occupational and environmental medicine, cardiology, and pulmonary medicine; medical students; and graduate students in epidemiology, toxicology, occupational and environmental hygiene, biostatistics, and environmental engineering. The program will include a research infrastructure (research assistance, data analysis, and biostatistics) and supervised research mentorship. The University of Washington provides an outstanding setting for collaborative training and patient-oriented research in environmental health sciences.

描述(由申请人提供) 这个拟议的职业生涯中期调查员奖的目标是扩大华盛顿大学专注于环境健康科学的多学科研究的培训。通过与几个正在进行的培训计划的合作，候选人Joel D.Kaufman，医学博士，公共卫生硕士，将扩展一个广泛的研究计划和指导计划，包括来自几个相关学科的受训者。在最初的K24奖项期间，考夫曼博士的研究生产率和指导能力在深度和广度上都得到了提高和加速。这一持续的计划将结合实验、流行病学和转化方法，研究环境因素在心血管疾病中的作用。这项拟议的研究结合了考夫曼博士正在进行的研究计划中的两个主题相关的项目。这两篇论文都阐述了与交通相关的空气污染通过对血管系统的急性和慢性影响而对心血管疾病产生影响的论点。其中一个项目研究了柴油尾气吸入对受控暴露下血管功能的影响，解决了了解氧化应激作用的机制假说。第二个项目以空气污染对心血管疾病影响的流行病学研究为基础，在一个基于多种族人群的队列中，研究了急性和慢性污染暴露对血管功能、动脉粥样硬化和表观基因组标志物的联合和独立影响。导师计划建立在考夫曼博士在多学科研究方面的成功基础上，旨在为来自不同学科的学员提供以患者为导向的环境健康科学研究方面的研究指导。他们将包括职业和环境医学、心脏病学和肺部医学的研究员；医学生；以及流行病学、毒理学、职业和环境卫生、生物统计学和环境工程的研究生。该计划将包括研究基础设施(研究援助、数据分析和生物统计学)和监督研究指导。华盛顿大学为环境健康科学方面的协作培训和以患者为中心的研究提供了一个出色的环境。