Training in Immunology and Molecular Pathogenesis

免疫学和分子发病机制培训

• 批准号: 8672581
• 负责人: Brian D Evavold
• 金额: $ 27.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8672581
• 关键词: Molecular Immunology; Pathogenesis; Training

DESCRIPTION (provided by applicant): This is the second competing renewal of a training program to provide high quality pre- and postdoctoral training in Immunology and Molecular Pathogenesis to the most qualified candidates. The faculty in the graduate Program in Immunology and Molecular Pathogenesis (IMP) have the expertise required to provide the foundation that is critical for outstanding predoctoral and postdoctoral training. Many of the participating faculty have extensive training records, in some cases initiated at their former institutions prior to their recruitment to Emory. The areas of research represented by this program have outstanding potential for future investigations and for providing new insights into disease pathogenesis. The research programs of the faculty fall into three main training areas: 1) pathogenesis of infectious diseases; 2) molecular virology; and 3) immunobiology. The faculty of IMP are members of six basic science or clinical departments in the School of Medicine, as well as Yerkes National Primate Center, the Biology Department of Emory College, and the U.S. Centers for Disease Control and Prevention (CDC). During the previous ten years of this training program, this grant has provided support for 48 predoctoral and 13 postdoctoral trainees. Two of the postdoctoral trainees are currently independent investigators (LaJolla Institute of Allergy and Immunology; UCSF) and two others have already received individual training awards to complete their postdoctoral work. Of the 48 predoctoral trainees, 27 are still in predoctoral training. Twenty students have received their Ph.D.s of which 1 is an Assistant Professor, 1 is a CDC staff scientist, 15 and are currently postdoctoral fellows. Of these 48 students supported by the training grant only one has left the program (a nearly 100% retention rate), which is better than the IMP program overall. Therefore this training grant has improved immunology and virology training at Emory, supporting not only our most outstanding students and postdocs, but enriching the intellectual environment by funding external speakers in the Program seminar series. RELEVANCE: The relevance for this training program includes the importance of interdisciplinary training in providing the foundation for investigating mechanisms of pathogenesis and the extensive previous involvement of the participating faculty in pre- and postdoctoral training. The availability of funds from this training grant has had a profound positive effect on immunology and virology training at Emory University.

描述（由申请人提供）：这是培训计划的第二次竞争性更新，为最合格的候选人提供高质量的免疫学和分子病理学博士前和博士后培训。在免疫学和分子病理学（IMP）研究生课程的教师有所需的专业知识，提供优秀的博士前和博士后培训至关重要的基础。许多参与的教师都有广泛的培训记录，在某些情况下，在他们被招聘到埃默里大学之前，他们的前机构开始。该计划所代表的研究领域具有出色的潜力，为未来的调查和提供新的见解疾病的发病机制。该学院的研究计划分为三个主要培训领域：1）传染病的发病机制; 2）分子病毒学;和3）免疫生物学。IMP的教师是医学院六个基础科学或临床部门的成员，以及耶基斯国家灵长类动物中心，埃默里学院生物系和美国疾病控制和预防中心（CDC）。在该培训计划的前十年中，这笔赠款为48名博士前和13名博士后学员提供了支持。其中两名博士后学员目前是独立的研究人员（拉霍亚过敏和免疫学研究所;加州大学旧金山分校），另外两名已经获得个人培训奖，以完成他们的博士后工作。在48名博士前学员中，有27人仍在接受博士前培训。20名学生获得了博士学位，其中1名是助理教授，1名是CDC的科学家，15名目前是博士后研究员。在这48名接受培训补助金支助的学生中，只有一名学生离开了方案（留存率接近100%），总体上优于IMP方案。因此，这项培训补助金改善了埃默里大学的免疫学和病毒学培训，不仅支持我们最优秀的学生和博士后，而且通过资助计划研讨会系列的外部演讲者来丰富知识环境。 相关性：该培训计划的相关性包括跨学科培训的重要性，为调查发病机制提供基础，以及参与教师在博士前和博士后培训中的广泛参与。该培训补助金的可用性对埃默里大学的免疫学和病毒学培训产生了深远的积极影响。

项目成果

Regulatory and T Effector Cells Have Overlapping Low to High Ranges in TCR Affinities for Self during Demyelinating Disease.

• DOI: 10.4049/jimmunol.1501464
• 发表时间: 2015-11-01
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Hood JD;Zarnitsyna VI;Zhu C;Evavold BD
• 通讯作者: Evavold BD

Generation of T cell receptor-retrogenic mice: improved retroviral-mediated stem cell gene transfer.

• DOI: 10.1038/nprot.2013.111
• 发表时间: 2013-10
• 期刊: Nature protocols
• 影响因子: 14.8

Lymphoid organogenesis in the intestine.

肠道中的淋巴器官发生。

• DOI: 10.1385/ir:33:2:167
• 发表时间: 2005
• 期刊: Immunologic research
• 影响因子: 4.4
• 作者: Taylor,RebekahT;Williams,IforR
• 通讯作者: Williams,IforR

Single-dose replication-defective VSV-based Nipah virus vaccines provide protection from lethal challenge in Syrian hamsters.

• DOI: 10.1016/j.antiviral.2013.10.012
• 发表时间: 2014-01
• 期刊: ANTIVIRAL RESEARCH
• 影响因子: 7.6
• 作者: Lo, Michael K.;Bird, Brian H.;Chattopadhyay, Anasuya;Drew, Clifton P.;Martin, Brock E.;Coleman, Joann D.;Rose, John K.;Nichol, Stuart T.;Spiropoulou, Christina F.
• 通讯作者: Spiropoulou, Christina F.

Shifts in geographic distribution and antimicrobial resistance during a prolonged typhoid fever outbreak--Bundibugyo and Kasese Districts, Uganda, 2009-2011.

伤寒长期爆发期间地理分布和抗菌药物耐药性的变化——乌干达本迪布焦和卡塞塞地区，2009-2011 年。

• DOI: 10.1371/journal.pntd.0002726
• 发表时间: 2014
• 期刊: PLoS neglected tropical diseases
• 影响因子: 3.8
• 作者: Walters,MaroyaSpalding;Routh,Janell;Mikoleit,Matthew;Kadivane,Samuel;Ouma,Caroline;Mubiru,Denis;Mbusa,Ben;Murangi,Amos;Ejoku,Emmanuel;Rwantangle,Absalom;Kule,Uziah;Lule,John;Garrett,Nancy;Halpin,Jessica;Maxwell,Nikki;Kagirit
• 通讯作者: Kagirit