Interactions between the ? and ? subunits of the DHPR - a missing link in skeletal muscle excitation-contraction coupling and a role in sarcopenia

之间的相互作用？

• 批准号: nhmrc : 1020589
• 负责人: A/Pr Aaron Oakley
• 金额: $ 46.06万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/interactions-subunits-dhpr-role-sarcopenia/110049
• 关键词: Interactions; between; subunits; DHPR; missing

Calcium signaling is disrupted in muscle diseases, including muscle weakness in the elderly. This is a significant problem as all mobility depends on calcium signaling and its disruption can cause serious disability and death. To alleviate defective calcium signaling, the underlying molecular machinery must be fully understood, yet we have only a broad outline of the processes. We will address this problem to provide a platform for alleviating age-related muscle weakness.

钙信号在肌肉疾病中被破坏，包括老年人的肌无力。这是一个重要的问题，因为所有的流动性都取决于钙信号，而钙信号的中断可能导致严重的残疾和死亡。为了减轻有缺陷的钙信号传导，必须充分了解潜在的分子机制，但我们只有一个大致的过程。我们将解决这个问题，为缓解与年龄相关的肌肉无力提供一个平台。