Targeting lagging strand DNA replication in model and pathogenic bacteria

越来越多的医院获得性感染不能用抗生素有效治疗，因为引起它们的细菌对药物治疗有抗药性。这个项目将发展我们对DNA如何在即将自我繁殖的细菌中复制的基本理解，我们将利用这些知识来发现阻止它们复制DNA的方法，从而杀死它们。这将为开发新的抗生素提供基础。

An increasing concern is the growing number of hospital acquired infections that cannot be treated effectively with antibiotics because the bacteria that cause them are resistant to drug treatments. This project will develop our basic understanding of how DNA is copied in bacteria that are about to reproduce themselves, and we will use this knowledge to discover ways to stop them from copying their DNA, thus killing them. This will provide the foundation for development of new antibiotics.