Targeting lagging strand DNA replication in model and pathogenic bacteria

靶向模型和病原菌中的滞后链 DNA 复制

• 批准号: nhmrc : 1007947
• 负责人: A/Pr Aaron Oakley
• 金额: $ 39.37万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-lagging-strand-pathogenic-bacteria/109259
• 关键词: Targeting; lagging; strand; DNA; replication

An increasing concern is the growing number of hospital acquired infections that cannot be treated effectively with antibiotics because the bacteria that cause them are resistant to drug treatments. This project will develop our basic understanding of how DNA is copied in bacteria that are about to reproduce themselves, and we will use this knowledge to discover ways to stop them from copying their DNA, thus killing them. This will provide the foundation for development of new antibiotics.

越来越令人担忧的是，越来越多的医院获得性感染无法用抗生素有效治疗，因为导致这些感染的细菌对药物治疗具有耐药性。这个项目将发展我们对DNA如何在即将自我繁殖的细菌中复制的基本理解，我们将利用这些知识来发现阻止它们复制DNA从而杀死它们的方法。这将为开发新的抗生素提供基础。