Epigenetic regulation by lysine specific demethylases in breast cancer stem cells.

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The factors behind breast cancer recurrence are not fully understood but it is becoming increasingly evident that the spread of primary cancer can be initiated at a very early stage of cancer development by a small population of unique cancer cells, termed cancer stem cells (CSCs). Targeting of these CSCs has emerged as a priority area in cancer therapy. Our aim is to demonstrate that a novel class of epigenetic enzymes are key molecular targets of CSCs and propose a strategy to eradicate CSCs.