Epigenetic regulation by lysine specific demethylases in breast cancer stem cells.

乳腺癌干细胞中赖氨酸特异性去甲基酶的表观遗传调控。

• 批准号: nhmrc : 1068065
• 负责人: A/Pr Aaron Oakley
• 金额: $ 39.4万
• 依托单位: University of Canberra
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-regulation-lysine-stem-cells/455331
• 关键词: Epigenetic; regulation; lysine; specific; demethylases

The factors behind breast cancer recurrence are not fully understood but it is becoming increasingly evident that the spread of primary cancer can be initiated at a very early stage of cancer development by a small population of unique cancer cells, termed cancer stem cells (CSCs). Targeting of these CSCs has emerged as a priority area in cancer therapy. Our aim is to demonstrate that a novel class of epigenetic enzymes are key molecular targets of CSCs and propose a strategy to eradicate CSCs.

乳腺癌复发背后的因素尚未完全了解，但越来越明显的是，原发性癌症的扩散可以在癌症发展的非常早期阶段由一小群独特的癌细胞（称为癌症干细胞（CSC））启动。靶向这些CSC已成为癌症治疗的优先领域。我们的目的是证明一类新的表观遗传酶是CSC的关键分子靶点，并提出根除CSC的策略。