Glutathione transferase Omega 1 as a novel target for sepsis and other inflammatory disorders.

谷胱甘肽转移酶 Omega 1 作为败血症和其他炎症性疾病的新靶标。

• 批准号: nhmrc : 1124673
• 负责人: A/Pr Aaron Oakley
• 金额: $ 47.45万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/glutathione-transferase-omega-inflammatory-disorders/947404
• 关键词: Glutathione; transferase; Omega; novel; target

Sepsis is a major clinical problem that causes more deaths in Australia than breast, prostate or colon cancer. The deaths result from an overwhelming systemic inflammatory response to infection. We have discovered that this response is dependent on an enzyme called GSTO1-1 and that inhibitors can block the inflammatory response . In this study we will identify new drug like compounds that can inhibit GSTO1-1 and prevent death from sepsis.

在澳大利亚，脓毒症是一个主要的临床问题，导致的死亡人数超过乳腺癌、前列腺癌或结肠癌。这些死亡是由于对感染的压倒性全身炎症反应造成的。我们已经发现，这种反应依赖于一种名为GSTO1-1的酶，而抑制剂可以阻断炎症反应。在这项研究中，我们将寻找能够抑制GSTO1-1和预防脓毒症死亡的新药。