A Stable Protein:DNA Complex for Development of Ultrasensitive Diagnostics in Multiplex Format

用于开发多重形式超灵敏诊断的稳定蛋白质：DNA 复合物

• 批准号: nhmrc : 514605
• 负责人: A/Pr Aaron Oakley
• 金额: $ 34.8万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/stable-proteindna-complex-multiplex-format/99350
• 关键词: Stable; Protein; DNA; Complex; Development

A new technology platform will be developed to carry out diagnostic tests in a multiplex format with increased sensitivity and precision. We recently discovered a very strong interaction between a protein and a particular fragment of DNA. This interaction can be tuned to enable its use for the simultaneous detection of different disease markers in a single assay. This will improve the time and space needed to perform diagnostic tests in laboratories.

将开发一个新的技术平台，以提高灵敏度和精确度，以多路传输的形式进行诊断测试。我们最近发现蛋白质和DNA的特定片段之间存在很强的相互作用。这种相互作用可以被调节，以使其能够用于在单一检测中同时检测不同的疾病标记物。这将改善在实验室进行诊断测试所需的时间和空间。