Decrypting the Excitation Contraction coupling machinery in skeletal muscle

解密骨骼肌中的兴奋收缩耦合机制

• 批准号: nhmrc : 1126201
• 负责人: A/Pr Aaron Oakley
• 金额: $ 62.47万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/decrypting-excitation-contraction-skeletal-muscle/947749
• 关键词: Decrypting; Excitation; Contraction; coupling; machinery

Skeletal muscle function is dependent upon the fine control of calcium levels. When communication of key proteins in muscle are compromised, calcium levels are uncontrolled leading to severe disabilities. The molecular pathways that control signalling between key muscle proteins is currently unknown and shedding light on this topic will aid in the discovery of therapies for muscle-associated disabilities in disease and with aging.

骨骼肌的功能依赖于对钙水平的精细控制。当肌肉中关键蛋白质的通讯受到影响时，钙水平就会失控，导致严重的残疾。控制关键肌肉蛋白之间信号传递的分子通路目前尚不清楚，揭示这一主题将有助于发现治疗疾病和衰老中肌肉相关残疾的方法。