Glutathione transferase Omega 1 as a novel target for sepsis and other inflammatory disorders.
Glutathione transferase Omega 1 as a novel target for sepsis and other inflammatory disorders.
批准号:
nhmrc : GNT1124673
负责人:
A/Pr Aaron Oakley
金额:
$69.45万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2017
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2017-01-01 至 --
中文摘要
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英文摘要
Sepsis is a major clinical problem that causes more deaths in Australia than breast, prostate or colon cancer. The deaths result from an overwhelming systemic inflammatory response to infection. We have discovered that this response is dependent on an enzyme called GSTO1-1 and that inhibitors can block the inflammatory response . In this study we will identify new drug like compounds that can inhibit GSTO1-1 and prevent death from sepsis.
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Glutathione transferase Omega 1 as a novel target for sepsis and other inflammatory disorders.
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批准号:nhmrc : 1124673
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项目类别:Project Grants
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资助金额:$47.45万
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财政年份:2017
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负责人:A/Pr Aaron Oakley
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依托单位:
Decrypting the Excitation Contraction coupling machinery in skeletal muscle
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批准号:nhmrc : GNT1126201
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项目类别:Project Grants
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资助金额:$91.49万
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财政年份:2017
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负责人:A/Pr Aaron Oakley
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依托单位:
Decrypting the Excitation Contraction coupling machinery in skeletal muscle
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批准号:nhmrc : 1126201
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项目类别:Project Grants
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资助金额:$62.47万
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财政年份:2017
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负责人:A/Pr Aaron Oakley
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依托单位:
Epigenetic regulation by lysine specific demethylases in breast cancer stem cells.
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批准号:nhmrc : 1068065
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项目类别:Project Grants
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资助金额:$39.4万
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财政年份:2014
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负责人:A/Pr Aaron Oakley
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依托单位:
Targeting nucleic acid synthesis and cell division in Gram-negative bacterial pathogens
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批准号:nhmrc : 1021479
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项目类别:Project Grants
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资助金额:$64.47万
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财政年份:2012
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负责人:A/Pr Aaron Oakley
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依托单位:
Interactions between the ? and ? subunits of the DHPR - a missing link in skeletal muscle excitation-contraction coupling and a role in sarcopenia
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批准号:nhmrc : 1020589
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项目类别:Project Grants
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资助金额:$46.06万
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财政年份:2012
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负责人:A/Pr Aaron Oakley
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依托单位:
Targeting lagging strand DNA replication in model and pathogenic bacteria
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批准号:nhmrc : 1007947
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项目类别:Project Grants
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资助金额:$39.37万
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财政年份:2011
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负责人:A/Pr Aaron Oakley
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依托单位:
A Stable Protein:DNA Complex for Development of Ultrasensitive Diagnostics in Multiplex Format
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批准号:nhmrc : 514605
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项目类别:NHMRC Project Grants
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资助金额:$34.8万
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财政年份:2008
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负责人:A/Pr Aaron Oakley
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依托单位:
Pharmacogenetic and structural investigation of the Omega class glutathione transferases
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批准号:nhmrc : 366731
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项目类别:NHMRC Project Grants
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资助金额:$32.67万
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财政年份:2006
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负责人:A/Pr Aaron Oakley
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依托单位:
国内基金
海外基金
miR-502与其靶基因SET8在乳腺癌中的功能研究
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批准号:81071627
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项目类别:面上项目
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资助金额:32.0万元
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批准年份:2010
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负责人:刘奔
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依托单位: