Targeting nucleic acid synthesis and cell division in Gram-negative bacterial pathogens

靶向革兰氏阴性细菌病原体的核酸合成和细胞分裂

• 批准号: nhmrc : 1021479
• 负责人: A/Pr Aaron Oakley
• 金额: $ 64.47万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-nucleic-acid-bacterial-pathogens/110126
• 关键词: Targeting; nucleic; acid; synthesis; cell

Some bacteria like Acinetobacter species cause infections in hospitals that are difficult to treat because they have acquired resistance to most antibiotics. This project will combine the complementary expertise of five research groups to develop knowledge of, and how to block, three essential processes in these worrying pathogenic species: copying of DNA, RNA synthesis, and cell division. This promises to lead to development of new antibacterial therapies.

一些细菌，如不动杆菌属，在医院引起感染，很难治疗，因为它们对大多数抗生素都有抗药性。该项目将联合收割机的五个研究小组的互补专业知识，开发知识，以及如何阻止，在这些令人担忧的病原体物种的三个基本过程：复制的DNA，RNA合成和细胞分裂。这有望导致新的抗菌疗法的发展。