CSHL 2014 Nuclear Receptors and Disease Conference

CSHL 2014核受体与疾病会议

• 批准号: 8825839
• 负责人: DAVID J. STEWART
• 金额: $ 2.3万
• 依托单位: COLD SPRING HARBOR LABORATORY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-23 至 2015-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8825839
• 关键词: Aging; Area; Basic Science; Binding; Cardiovascular Diseases; Cell physiology; Cells; Chemicals; Chromatin; Clinical; Clinical Research; Collaborations; Complex; DNA; Data; Development; Diabetes Mellitus; Disease; Ensure; Environment; Etiology; Faculty; Fostering; Gender; Gene Expression; Genetic; Genetic Transcription; Genome; Geography; Growth; Individual; International; Laboratories; Lead; Length of Stay; Malignant neoplasm of prostate; Metabolic; Metabolic Diseases; Metabolism; Methodology; Molecular Biology; Molecular Mechanisms of Action; Nuclear Receptors; Obesity; Oral; Organism; Participant; Pharmacology; Physiological; Physiology; Play; Postdoctoral Fellow; Protein Binding; Proteins; Published Comment; Reagent; Regulation; Research; Research Personnel; Role; Schedule; Scientist; Senior Scientist; Series; Signal Transduction; Staging; Structure; System; Technology; Work; abstracting; base; cancer type; career; cell growth; graduate student; human NRBP protein; human disease; insight; interest; laboratory facility; malignant breast neoplasm; meetings; novel; planetary Atmosphere; posters; preference; public health relevance; receptor; response; sensor; symposium; therapy development; tumor metabolism; unpublished works

DESCRIPTION (provided by applicant): Cold Spring Harbor Laboratory Conference on Nuclear Receptors and Disease October 28 - November 1, 2014 Project Summary This proposal seeks support for the meeting on "Nuclear Receptors and Disease" to be held at Cold Spring Harbor Laboratory October 28 - November 1, 2014. The meeting will assemble leaders in the field, together with junior faculty, postdoctoral fellows and graduate students, to discuss the latest advances in our understanding of the physiological and cellular function of nuclear receptors as well as their role in human diseases. Nuclear receptors are proteins that bind to DNA and regulate gene expression in response to small "messenger" molecules that bind to the receptors. By means of this messenger-receptor system important information about the environment and the metabolic condition of the cell is communicated to the genome, thereby leading to changes in gene expression. Nuclear receptors play very important roles as regulators of cellular growth, differentiation and metabolism, and dysregulation of these receptors can lead to metabolic diseases and different types of cancer. The meeting will cover a broad spectrum of topics ranging from detailed molecular mechanism of action to clinical implications at the organismal level. Each session will be chaired by a leading scientist in the field. Oral presentations will be given by a group of distinguished invited speakers as well as speakers selected from submitted abstracts. Selected speakers will include graduate students, postdoctoral fellows and junior faculty, aiming for maximal inclusion of young investigators. Of special importance are the two poster sessions, where many participants will present their work in an atmosphere conducive to informal discussion. The meeting will be of moderate size. We expect about 250 people to attend, the vast majority of whom will be presenting a poster or talk.

描述（由申请人提供）：冷泉港实验室会议核受体和疾病2014年10月28日至11月1日项目摘要本提案寻求对“核受体和疾病”会议的支持，该会议将于2014年10月28日至11月1日在冷泉港实验室举行。会议将汇集该领域的领导者，与初级教师，博士后研究员和研究生一起，讨论我们对核受体的生理和细胞功能以及它们在人类疾病中的作用的理解的最新进展。 核受体是与DNA结合并响应于与受体结合的小“信使”分子而调节基因表达的蛋白质。通过这种信使-受体系统，有关细胞环境和代谢状况的重要信息被传递到基因组，从而导致基因表达的变化。核受体作为细胞生长、分化和代谢的调节剂起着非常重要的作用，并且这些受体的失调可导致代谢疾病和不同类型的癌症。 会议将涵盖广泛的主题，从详细的分子作用机制到生物体水平的临床意义。每次会议将由该领域的一位顶尖科学家主持。将由一组杰出的特邀演讲者以及从提交的摘要中选出的演讲者作口头介绍。选定的演讲者将包括研究生，博士后研究员和初级教师，旨在最大限度地纳入年轻的研究人员。特别重要的是两次海报会议，许多与会者将在有利于非正式讨论的气氛中介绍他们的工作。会议规模将不大。我们预计约有250人参加，其中绝大多数将展示海报或演讲。